The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …

As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue
growth two decades ago and has been a subject extensively studied in both Drosophila and …

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ)
are two homologous transcriptional coactivators that promote cell proliferation, stem cell …

The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue
homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss …

The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated
anabolic program in response to growth-promoting signals. Paradoxically, recent studies …

Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …

Tissue repair and regenerative medicine address the important medical needs to replace
damaged tissue with functional tissue. Most regenerative medicine strategies have focused …

The primary mechanisms supporting immunoregulatory polarization of myeloid cells upon
infiltration into tumors remain largely unexplored. Elucidation of these signals could enable …