Alzheimer's disease (AD) is a progressive, neurodegenerative disease and the most
common form of dementia in elderly people. It is an emerging public health problem that …

Spleen tyrosine kinase (Syk) is a cytosolic non-receptor protein tyrosine kinase (PTK) and is
mainly expressed in hematopoietic cells. Syk was recognized as a critical element in the B …

Microglia and neuroinflammation play an important role in the development and progression
of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a …

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy associated with
Notch pathway mutations. While both normal activated and leukemic T cells can utilize …

Inhibitory leukocyte immunoglobulin-like receptors (LILRBs 1-5) transduce signals via
intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein …

Hematological malignancies (HM) are a collection of malignant transformations originating
from cells in the primary or secondary lymphoid organs. Leukemia, lymphoma, and multiple …

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous diagnostic category comprising
distinct molecular subtypes characterized by diverse genetic aberrations that dictate patient …

Current therapeutic approaches for chronic lymphocytic leukemia (CLL) focus on the
suppression of oncogenic kinase signaling. Here, we test the hypothesis that targeted …

Acute myeloid leukemia (AML) and the myelodysplastic syndromes (MDS) are initiated and
sustained by self-renewing malignant stem cells; thus, eradication of AML and MDS stem …

The phosphoinositide phosphatase SHIP is a critical regulator of immune cell activation.
Despite considerable study, the mechanisms controlling SHIP activity to ensure balanced …