Accurate measurement of cortisol is critical in adrenal insufficiency as it reduces the risk
associated with misdiagnosis and supports the optimization of stress dose. Comprehensive …

Objective: The definition of normal adrenal function in critically ill patients remains
controversial, despite a large body of literature. We review the clinical presentation …

This work proposed a novel and flexible immunosensor for highly selective and sensitive
determination of cortisol in sweat. The flexible electrode was developed by transferring multi …

Background Acute Respiratory Distress Syndrome (ARDS) is a devastating pulmonary
inflammatory disorder, commonly precipitated by sepsis. Glucocorticoids are …

Purpose To determine if adrenocortical gene expression is associated with clinical
outcomes or response to corticosteroid treatment in septic shock. Methods A pre-specified …

Introduction Adiponectin plays an important role in the regulation of tissue inflammation and
insulin sensitivity. Perturbations in adiponectin concentration have been associated with …

Critical illness is generally hallmarked by activation of the hypothalamic–pituitary–adrenal
axis. The development of very high levels of cortisol has been associated with severe illness …

Two randomised controlled trials have reported a reduction in mortality when adjunctive
hydrocortisone is administered in combination with fludrocortisone compared with placebo …

Introduction Neuropeptides arginine-vasopressin (AVP), apelin (APL), and stromal-derived
factor-1α (SDF-1α) are involved in the dysfunction of the corticotropic axis observed in septic …

The glucocorticoid receptor (GCR) and the mineralocorticoid receptor (MR) are members of
the steroid receptor superfamily of hormone-dependent transcription factors. The receptors …