Non-small-cell lung cancers: a heterogeneous set of diseases

Z Chen, CM Fillmore, PS Hammerman, CF Kim… - Nature Reviews …, 2014 - nature.com
Non-small-cell lung cancers (NSCLCs), the most common lung cancers, are known to have
diverse pathological features. During the past decade, in-depth analyses of lung cancer …

Melatonin in cancer treatment: current knowledge and future opportunities

WH Talib, AR Alsayed, A Abuawad, S Daoud… - Molecules, 2021 - mdpi.com
Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and
experimental studies have documented that melatonin could inhibit different types of cancer …

[HTML][HTML] Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5

Y Liu, X Liu, N Zhang, M Yin, J Dong, Q Zeng… - … Pharmaceutica Sinica B, 2020 - Elsevier
Abstract Programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) blocking
therapy has become a major pillar of cancer immunotherapy. Compared with antibodies …

Changes in CT radiomic features associated with lymphocyte distribution predict overall survival and response to immunotherapy in non–small cell lung cancer

M Khorrami, P Prasanna, A Gupta, P Patil… - Cancer immunology …, 2020 - aacrjournals.org
No predictive biomarkers can robustly identify patients with non–small cell lung cancer
(NSCLC) who will benefit from immune checkpoint inhibitor (ICI) therapies. Here, in a …

An individual patient data metaanalysis of outcomes and prognostic factors after treatment of oligometastatic non–small-cell lung cancer

AB Ashworth, S Senan, DA Palma, M Riquet, YC Ahn… - Clinical lung cancer, 2014 - Elsevier
Abstract Introduction/Background An individual patient data metaanalysis was performed to
determine clinical outcomes, and to propose a risk stratification system, related to the …

Novel Targets in Non‐Small Cell Lung Cancer: ROS1 and RET Fusions

JF Gainor, AT Shaw - The oncologist, 2013 - academic.oup.com
The discovery of chromosomal rearrangements involving the anaplastic lymphoma kinase
(ALK) gene in non‐small cell lung cancer (NSCLC) has stimulated renewed interest in …

m5C RNA methylation regulators predict prognosis and regulate the immune microenvironment in lung squamous cell carcinoma

J Pan, Z Huang, Y Xu - Frontiers in Oncology, 2021 - frontiersin.org
RNA methylation is a novel epigenetic modification that can be used to evaluate tumor
prognosis. However, the underlying mechanisms are unclear. This study aimed to …

National Comprehensive Cancer Network (NCCN) clinical practice guidelines for lung cancer screening

DE Wood - Thoracic surgery clinics, 2015 - thoracic.theclinics.com
The National Comprehensive Cancer Network (NCCN) is a not-for-profit alliance of 25 of the
world's leading cancer centers that are devoted to patient care, research, and education …

Recent clinical advances in lung cancer management

DH Johnson, JH Schiller, PA Bunn Jr - Journal of clinical oncology, 2014 - ascopubs.org
Progress has been made in the treatment of lung cancer over the past 40 years, albeit at a
modest pace. Cytoxic chemotherapy has improved 5-year survival rates when added to …

The lncRNA MALAT1 contributes to non‐small cell lung cancer development via modulating miR‐124/STAT3 axis

S Li, Z Mei, HB Hu, X Zhang - Journal of Cellular Physiology, 2018 - Wiley Online Library
lncRNAs can exert many biological effects in several cancer types. MALAT1 is a kind of
lncRNA which is greatly overexpressed in several tumors including non‐small cell lung …