Intracranial aneurysms (IA) are local dilatations in cerebral arteries that predominantly affect
the circle of Willis. Occurring in approximately 2–5% of adults, these weakened areas are …

Coronary artery disease (CAD) is the leading form of cardiovascular disease (CVD), which is
the primary cause of mortality worldwide. It is a complex disease with genetic and …

During animal embryogenesis, homeostasis and disease, tissues push and pull on their
surroundings to move forward. Although the force-generating machinery is known, it is …

Throughout development, tissues undergo dynamic morphogenetic rearrangements to form
complex structures. Active cellular processes, including migration, proliferation, and cell …

Intratumoral hypoxia correlates with metastasis and poor survival in patients with sarcoma.
Using an impedance sensing assay and a zebrafish intravital microinjection model, we …

Hematopoietic stem cells (HSCs) emerge from hemogenic endothelium (HE) within the
ventral portion of the dorsal aorta during vertebrate development. In zebrafish, Notch …

The assembly of a mature vascular network involves coordinated endothelial cell (EC)
shape changes, including the process of EC elongation. How EC elongation is dynamically …

In order to efficiently derive hematopoietic stem cells (HSCs) from pluripotent precursors, it is
crucial to understand how mesodermal cells acquire hematopoietic and endothelial …

Circulation is required for the delivery of oxygen and nutrition to tissues and organs, as well
as waste collection. Therefore, the heart and vessels develop first during embryogenesis …

As a signal molecule, nitric oxide (NO) has several physiological actions in fish. However,
the action of NO on the brain/gut axis, a classic inter-organal axis that bridges the …