Melatonin is remarkably functionally diverse with actions as a free radical scavenger and
antioxidant, circadian rhythm regulator, anti‐inflammatory and immunoregulating molecule …

Regular exercise has multi-system anti-aging effects. Here we summarize how exercise
impacts the major hallmarks of aging. We propose that, besides searching for novel …

Mitochondrial DNA (mtDNA) lacks the protection provided by the nucleosomes in the
nuclear DNA and does not have a DNA repair mechanism, making it highly susceptible to …

The purpose of the current study was to investigate the effect of the recently synthesized
mitochondrially-targeted H 2 S donor, AP39 [(10-oxo-10-(4-(3-thioxo-3H-1, 2-dithiol-5yl) …

Significance: There is increasing evidence that the generation of reactive oxygen species
(ROS) in the central nervous system (CNS) involves the NOX family of nicotinamide adenine …

The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

In the past century, considerable efforts were made to understand the role of mitochondrial
DNA (mtDNA) mutations and of oxidative stress in aging. The classic mitochondrial free …

Aging frailty is a complex geriatric syndrome that becomes more prevalent with advancing
age. It constitutes a major health problem due to frequent adverse outcomes. Frailty is …

Melatonin is known to possess several properties of value for healthy aging, as a direct and
indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic …

Disuse situations can have serious adverse health consequences in the elderly, including
mainly functional impairment with subsequent increase in the risk of falls or morbimortality …