A review on advancements in feature selection and feature extraction for high-dimensional NGS data analysis

K Borah, HS Das, S Seth, K Mallick, Z Rahaman… - Functional & Integrative …, 2024 - Springer
Recent advancements in biomedical technologies and the proliferation of high-dimensional
Next Generation Sequencing (NGS) datasets have led to significant growth in the bulk and …

PDGFRα+ ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay

H Zheng, M An, Y Luo, X Diao, W Zhong, M Pang, Y Lin… - Cancer Cell, 2024 - cell.com
Cancer-associated fibroblasts (CAFs) exhibit considerable heterogeneity in advanced
cancers; however, the functional annotation and mechanism of CAFs in early-stage cancers …

Artificial Intelligence in Point-of-Care Biosensing: Challenges and Opportunities

CD Flynn, D Chang - Diagnostics, 2024 - mdpi.com
The integration of artificial intelligence (AI) into point-of-care (POC) biosensing has the
potential to revolutionize diagnostic methodologies by offering rapid, accurate, and …

Multi‑omics identification of a signature based on malignant cell-associated ligand–receptor genes for lung adenocarcinoma

S Xu, X Chen, H Ying, J Chen, M Ye, Z Lin, X Zhang… - BMC cancer, 2024 - Springer
Purpose Lung adenocarcinoma (LUAD) significantly contributes to cancer-related mortality
worldwide. The heterogeneity of the tumor immune microenvironment in LUAD results in …

Effector memory–type regulatory T cells display phenotypic and functional instability

DJ Wendering, L Amini, S Schlickeiser… - Science …, 2024 - science.org
Regulatory T cells (Treg cells) hold promise for sustainable therapy of immune disorders.
Recent advancements in chimeric antigen receptor development and genome editing aim to …

Comprehensive application of AI algorithms with TCR NGS data for glioma diagnosis

K Zhou, Z **ao, Q Liu, X Wang, J Huo, X Wu, X Zhao… - Scientific Reports, 2024 - nature.com
T-cell receptor (TCR) detection can examine the extent of T-cell immune responses.
Therefore, the article analyzed characteristic data of glioma obtained by DNA-based TCR …

The effect of data transformation on low-dimensional integration of single-cell RNA-seq

Y Park, AC Hauschild - BMC bioinformatics, 2024 - Springer
Background Recent developments in single-cell RNA sequencing have opened up a
multitude of possibilities to study tissues at the level of cellular populations. However, the …

Identifying genetic signatures from single-cell rna sequencing data by matrix imputation and reduced set gene clustering

S Seth, S Mallik, A Islam, T Bhadra, A Roy, PK Singh… - Mathematics, 2023 - mdpi.com
In this current era, the identification of both known and novel cell types, the representation of
cells, predicting cell fates, classifying various tumor types, and studying heterogeneity in …

[HTML][HTML] Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson's disease associated with nuclear receptor-related factor 1 …

PA Kambey, WY Liu, J Wu, B Bosco… - Neural Regeneration …, 2023 - journals.lww.com
Previous studies have found that deficiency in nuclear receptor-related factor 1 (Nurr1),
which participates in the development, differentiation, survival, and degeneration of …

Detailed social network interactions and gut microbiome strain-sharing within isolated Honduras villages

J Pullman, F Beghini, M Alexander, SV Shridhar… - bioRxiv, 2023 - biorxiv.org
When humans assemble into face-to-face social networks, they create an extended
environment that permits exposure to the microbiome of other members of a population …