Pathways of unconventional protein secretion

C Rabouille - Trends in cell biology, 2017 - cell.com
Secretory proteins are conventionally transported through the endoplasmic reticulum to the
Golgi and then to the plasma membrane where they are released into the extracellular …

Biogenesis and function of ESCRT-dependent extracellular vesicles

T Juan, M Fürthauer - Seminars in cell & developmental biology, 2018 - Elsevier
From bacteria to humans, cells secrete a large variety of membrane-bound extracellular
vesicles. Only relatively recently has it however started to become clear that the exovesicular …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Cellular functions and molecular mechanisms of the ESCRT membrane-scission machinery

L Christ, C Raiborg, EM Wenzel, C Campsteijn… - Trends in biochemical …, 2017 - cell.com
The endosomal sorting complex required for transport (ESCRT) machinery is an assembly of
protein subcomplexes (ESCRT I-III) that cooperate with the ATPase VPS4 to mediate …

A translocation pathway for vesicle-mediated unconventional protein secretion

M Zhang, L Liu, X Lin, Y Wang, Y Li, Q Guo, S Li, Y Sun… - Cell, 2020 - cell.com
Many cytosolic proteins lacking a signal peptide, called leaderless cargoes, are secreted
through unconventional secretion. Vesicle trafficking is a major pathway involved. It is …

Structures, functions, and dynamics of ESCRT-III/Vps4 membrane remodeling and fission complexes

J McCullough, A Frost… - Annual review of cell and …, 2018 - annualreviews.org
The endosomal sorting complexes required for transport (ESCRT) pathway mediates
cellular membrane remodeling and fission reactions. The pathway comprises five core …

The ESCRT-machinery: closing holes and expanding roles

AT Gatta, JG Carlton - Current opinion in cell biology, 2019 - Elsevier
The ESCRT machinery is an ancient, evolutionarily conserved membrane remodelling
complex that is deployed by cells to perform a diverse collection of physiological and …

The endolysosomal system in conventional and unconventional protein secretion

E Néel, M Chiritoiu-Butnaru, W Fargues… - Journal of Cell …, 2024 - rupress.org
Most secreted proteins are transported through the “conventional” endoplasmic reticulum–
Golgi apparatus exocytic route for their delivery to the cell surface and release into the …

[HTML][HTML] Through the back door: unconventional protein secretion

MJ Cohen, WJ Chirico, PN Lipke - The Cell Surface, 2020 - Elsevier
Proteins are secreted from eukaryotic cells by several mechanisms besides the well-
characterized classical secretory system. Proteins destined to enter the classical secretory …

Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis

V Choudhary, O El Atab, G Mizzon, WA Prinz… - Journal of Cell …, 2020 - rupress.org
Lipid droplets (LDs) are fat storage organelles that originate from the endoplasmic reticulum
(ER). Relatively little is known about how sites of LD formation are selected and which …