Nanoparticles in drug delivery: From history to therapeutic applications

O Afzal, ASA Altamimi, MS Nadeem, SI Alzarea… - Nanomaterials, 2022 - mdpi.com
Current research into the role of engineered nanoparticles in drug delivery systems (DDSs)
for medical purposes has developed numerous fascinating nanocarriers. This paper reviews …

The uniqueness of albumin as a carrier in nanodrug delivery

A Spada, J Emami, JA Tuszynski… - Molecular …, 2021 - ACS Publications
Albumin is an appealing carrier in nanomedicine because of its unique features. First, it is
the most abundant protein in plasma, endowing high biocompatibility, biodegradability …

[HTML][HTML] Anticancer drugs: recent strategies to improve stability profile, pharmacokinetic and pharmacodynamic properties

G Ioele, M Chieffallo, MA Occhiuzzi, M De Luca… - Molecules, 2022 - mdpi.com
In past decades, anticancer research has led to remarkable results despite many of the
approved drugs still being characterized by high systemic toxicity mainly due to the lack of …

The development of human serum albumin-based drugs and relevant fusion proteins for cancer therapy

H Tao, R Wang, W Sheng, Y Zhen - International journal of biological …, 2021 - Elsevier
Human serum albumin (HSA)-based therapeutics have attracted tremendous attention in the
development of anticancer agents. The versatile properties of HSA make HSA-based …

Injectable thermosensitive hydrogel containing erlotinib‐loaded hollow mesoporous silica nanoparticles as a localized drug delivery system for NSCLC therapy

X Zhou, X He, K Shi, L Yuan, Y Yang, Q Liu… - Advanced …, 2020 - Wiley Online Library
Erlotinib (ERT), oral administration agents, is one of the most pivotal targeted drugs in the
treatment of non‐small cell lung cancer (NSCLC); however, its poor solubility, low oral …

HER2‐positive breast cancer brain metastasis: a new and exciting landscape

AS Zimmer, AED Van Swearingen… - Cancer …, 2022 - Wiley Online Library
Abstract Background Brain metastases (BrM) incidence is 25% to 50% in women with
advanced human epidermal growth factor receptor 2 (HER2)‐positive breast cancer …

CDKN2A-mediated molecular subtypes characterize the hallmarks of tumor microenvironment and guide precision medicine in triple-negative breast cancer

T Cheng, Y Wu, Z Liu, Y Yu, S Sun, M Guo… - Frontiers in …, 2022 - frontiersin.org
Currently, breast cancer (BRCA) has become the most common cancer in the world, whose
pathological mechanism is complex. Among its subtypes, triple-negative breast cancer …

Engineered bacteria enhance immunotherapy and targeted therapy through stromal remodeling of tumors

SC Thomas, T Madaan, NS Kamble… - Advanced …, 2022 - Wiley Online Library
Desmoplastic solid tumors are characterized by the rapid build‐up of extracellular matrix
(ECM) macromolecules, such as hyaluronic acid (HA). The resulting physiological barrier …

Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway

D Massihnia, A Galvano, D Fanale, A Perez… - …, 2016 - pmc.ncbi.nlm.nih.gov
Breast cancer is one of the most widespread carcinoma and one of the main causes of
cancer-related death worldwide, especially in women aged between 35 and 75 years …

Albumin-based cancer therapeutics for intraperitoneal drug delivery: a review

L Van de Sande, S Cosyns, W Willaert, W Ceelen - Drug delivery, 2020 - Taylor & Francis
Albumin is a remarkable carrier protein with multiple cellular receptor and ligand binding
sites, which are able to bind and transport numerous endogenous and exogenous …