Accessing depth-resolved high spatial frequency content from the optical coherence tomography signal

S Alexandrov, A Arangath, Y Zhou, M Murphy… - Scientific Reports, 2021 - nature.com
Optical coherence tomography (OCT) is a rapidly evolving technology with a broad range of
applications, including biomedical imaging and diagnosis. Conventional intensity-based …

Skin cancer margin detection using nanosensitive optical coherence tomography and a comparative study with confocal microscopy

R Dey, S Alexandrov, P Owens, J Kelly… - Biomedical Optics …, 2022 - opg.optica.org
Excision biopsy and histology represent the gold standard for morphological investigation of
the skin, in particular for cancer diagnostics. Nevertheless, a biopsy may alter the original …

Characterization of nanosensitive multifractality in submicron scale tissue morphology and its alteration in tumor progression

N Das, S Alexandrov, KE Gilligan… - … of biomedical optics, 2021 - spiedigitallibrary.org
Significance: Assessment of disease using optical coherence tomography is an actively
investigated problem, owing to many unresolved challenges in early disease detection …

Nanosensitive optical coherence tomography for detecting structural changes in stem cells

A Arangath, N Duffy, S Alexandrov, S James… - Biomedical Optics …, 2023 - opg.optica.org
Mesenchymal stromal cells (MSCs) are adult stem cells that have been widely investigated
for their potential to regenerate damaged and diseased tissues. Multiple pre-clinical studies …

Indirectly assessing changes in corneal properties with OCT speckle after crosslinking in porcine eyes

ME Danielewska, MA Kostyszak, P Sareło… - Experimental Eye …, 2022 - Elsevier
The aim of this study was to assess the effect of the standard crosslinking (CXL) procedure
on corneal properties and subsequent changes in collagen bonds formation using optical …

Synthetic Fourier Domain Optical Coherence Tomography

S Alexandrov, R McAuley, R Dey… - Advanced Photonics …, 2024 - Wiley Online Library
A novel approach for image formation in optical coherence tomography (OCT) and
microscopy is presented. The depth resolution of OCT, including recently developed …

Nanoscale structure detection and monitoring of tumour growth with optical coherence tomography

N Das, A Sergey, Y Zhou, KE Gilligan, RM Dwyer… - Nanoscale …, 2020 - pubs.rsc.org
Approximately 90% of cancers originate in epithelial tissues leading to epithelial thickening,
but the ultrastructural changes and underlying architecture are less well known. Depth …

Simple characterization scheme for optical coherence tomography systems with application to a commercial and a near-isometric resolution fibre-based system

R Dey, Y Zhou, K Neuhaus, S Alexandrov… - IEEE Photonics …, 2021 - ieeexplore.ieee.org
Optical Coherence Tomography (OCT) is a rapidly growing imaging modality in biomedical
optics. OCT can perform high-resolution, cross-sectional imaging of the microstructure of …

Label free nano-sensitive optical imaging beyond resolution limit of the imaging system

S Alexandrov, R McAuley, R Dey… - 2024 24th International …, 2024 - ieeexplore.ieee.org
In this paper, we describe different approaches to improve resolution and get information
about structure beyond the resolution limit of the imaging system. The approaches are …

Decreased Central and Limbal Epithelium Thickness After Corneal Crosslinking Evaluated by Anterior Segment Optic Coherence Tomography

H GÜÇLÜ, İ AKARAY, Ö KAYA - 2021 - researchsquare.com
Aim: To Investigate the central cornea, limbal epithelium thickness and stroma thickness
after corneal cross-linking by Anterior Segment Optical Coherence Tomography (AS-OCT) …