Traditional descriptions of the hydrophobic effect on the basis of entropic arguments or the
calculation of solvent‐occupied surfaces must be questioned in view of new results obtained …

Nucleic acids are excellent at recognizing complementary sequences through the formation
of Watson− Crick base pairs. Since the base pairing enables the highly selective …

Water is essential for life in many ways, and without it biomolecules might no longer truly be
biomolecules. In particular, water is important to the structure, stability, dynamics, and …

Throughout human history, inexhaustible emerging or re-emerging pathogenic bacteria
have never ceased to pose significant challenges to global public health. As the other side …

The iconic helical structure of DNA is stabilized by the solvation environment, where a
change in the hydration state can lead to dramatic changes to the DNA structure. X-ray …

Binding of proteins to particular DNA sites across the genome is a primary determinant of
specificity in genome maintenance and gene regulation. DNA-binding specificity is encoded …

Tyrosine-type site-specific recombinases (T-SSRs) have opened new avenues for the
predictable modification of genomes as they enable precise genome editing in heterologous …

To characterize protein–RNA recognition at the molecular level, structural biology has
turned out to be an indispensable approach. Detailed and direct insights into the mechanism …

The value of thoroughly understanding the thermodynamics specific to a drug
discovery/design study is well known. Over the past decade, the crucial roles of water …

The structure of liquid water and its interaction with biological molecules is a very active area
of experimental and theoretical research. The chemically complex surfaces of protein …