Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

Fibrinogen and fibrin are essential for hemostasis and are major factors in thrombosis,
wound healing, and several other biological functions and pathological conditions. The X …

The formation of fibrin clots that are relatively resistant to lysis represents the final step in
blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in …

Elevated plasma clot lysis time (CLT) increases risk of venous and arterial thrombosis. It is
unclear which fibrinolytic factors contribute to thrombosis risk. In 743 healthy control subjects …

Homocysteine, a non-protein amino acid, is an important risk factor for ischemic heart
disease and stroke in humans. This review provides an overview of homocysteine influence …

We tested the hypothesis that fibrin structure/function is unfavorably altered in patients after
idiopathic venous thromboembolism (VTE) and their relatives. Ex vivo plasma fibrin clot …

The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains
unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent …

Accumulating evidence indicates that accelerated formation of fibrin clots composed of
compact, highly-branched networks with thin fibres which are relatively resistant to plasmin …

Cardiovascular disease (CVD) is the leading cause of mortality in the Western world. The
effort of research should aim at the primary prevention of CVD. Alongside statin therapy …

Accumulating evidence suggests that homocysteine (Hcy) metabolite, the thioester Hcy-
thiolactone, plays an important role in atherothrombosis. Hcy-thiolactone is a product of an …