This article covers the airway tree with respect to anatomy, pathology, and physiology. The
anatomic portion discusses various primate groups so as to help investigators understand …

This review evaluates the current status of information regarding the nonhuman primate as
an experimental model for defining mechanisms of chronic airways disease in humans …

Background Accurate characterization of asthma severity is difficult due to the variability of
symptoms. Hyperpolarized helium-3 MRI (H 3 HeMR) is a new technique in which the …

Purpose: To determine changes in regional airflow obstruction over time in the lungs of
patients with asthma, as demonstrated with hyperpolarized helium 3 (3He) magnetic …

BACKGROUND: It is unknown whether focal changes of airflow obstruction within the lungs
of patients with asthma vary or are fixed in location with time or repeated …

Adults and children may have different reactions to inhalation exposures due to differences
in target tissue doses following similar exposures, and/or different stages in lung growth and …

Background: Smoking induces structural changes in the airways, and is considered a major
factor in the development of airflow obstruction in chronic obstructive pulmonary disease …

Asthma is a chronic inflammatory airway disease driven by various infiltrating immune cell
types into the lung. Optical microscopy has been used to study immune infiltrates in …

The epithelium-associated cytokine thymic stromal lymphopoietin (TSLP) can induce OX40L
and CCL17 expression by myeloid dendritic cells (mDCs), which contributes to aberrant Th2 …

The recent, dramatic increase in the incidence of childhood asthma suggests a role for
environmental contaminants in the promotion of interactions between allergens and the …