Depression is a common and serious disorder, characterized by symptoms like anhedonia,
lack of energy, sad mood, low appetite, and sleep disturbances. This disease is very …

Optogenetic tools have provided a new way to establish causal relationships between brain
activity and behaviour in health and disease. Although no animal model captures human …

Research has elucidated causal links between stress exposure and the development of
anxiety disorders, but due to the limited use of female or sex-comparative animal models …

About one million suicides and ten million suicide attempts occur worldwide each year.
Suicide is not simply a response to stress, but generally a complication of a psychiatric …

Objective: Suicide, a major cause of death worldwide, has distinct biological underpinnings.
The authors review and synthesize the research literature on biomarkers of suicide, with the …

The metabolism of the amino acid l-tryptophan is a highly regulated physiological process
leading to the generation of several neuroactive compounds within the central nervous …

There is a growing appreciation of the importance of gut microbiota to health and disease.
This has been driven by advances in sequencing technology and recent findings …

Suicide is a major public health concern and a leading cause of death in most societies.
Suicidal behaviour is complex and heterogeneous, likely resulting from several causes. It …

Early-life stress is associated with a high prevalence of mental illnesses such as post-
traumatic stress disorders, attention-deficit/hyperactivity disorder, schizophrenia, and anxiety …

The concept that genetic factors contribute to the complex trait of suicidal behaviour has
stimulated much work aimed at identifying susceptibility genes. So far molecular genetic …