I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

Contributing Authors Isam Alobid, MD, PhD1, Nithin D. Adappa, MD2, Henry P. Barham,
MD3, Thiago Bezerra, MD4, Nadieska Caballero, MD5, Eugene G. Chang, MD6, Gaurav …

Objectives We conducted a systematic literature review (SLR) to determine the
epidemiology and clinical burden of chronic rhinosinusitis with nasal polyps (CRSwNP) and …

Chronic rhinosinusitis (CRS) is a public health problem that has a significant socio-
economic impact. Moreover, the complexity of this disease due to its heterogeneous nature …

Discerning the genetics and epigenetics of chronic rhinosinusitis (CRS) may optimize
outcomes through early diagnostics, personalized and novel therapeutics, and early …

The cause of chronic rhinosinusitis (CRS) remains unclear. Study of the genetic
susceptibility to CRS might be a valuable strategy to understand the pathogenesis of this …

Chronic rhinosinusitis (CRS) can be traditionally classified as CRSwNP [with nasal polyps
(NPs)] and CRSsNP (without NPs) based on the clinical phenotypes but recently suggested …

Chronic rhinosinusitis (CRS) is a significant public health problem. Bacterial colonization
and impaired mucociliary clearance play a significant role in the inflammatory process …

Purpose The role of the microbiome in the paranasal sinuses and its contribution to sinus
mucosal health and disease remains poorly understood. Consequently, we examined the …

Background The pathogenesis of chronic rhinosinusitis with nasal polyps is largely
unknown. Previous studies have given valuable information about genetic variants …