Wound healing is a complex, dynamic process supported by a myriad of cellular events that
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …

Various factors could damage the structure and integrity of skin to cause wounds.
Nonhealing or chronic wounds seriously affect the well-being of patients and bring heavy …

Cutaneous injuries, especially chronic wounds, burns, and skin wound infection, require
painstakingly long-term treatment with an immense financial burden to healthcare systems …

The cells secrete extracellular vesicles (EV) that may have an endosomal origin, or from
evaginations of the plasma membrane. The former are usually called exosomes, with sizes …

Significance: Chronic wounds include, but are not limited, to diabetic foot ulcers, venous leg
ulcers, and pressure ulcers. They are a challenge to wound care professionals and …

Aging is the result of a gradual functional decline at the cellular, and ultimately, organismal
level, resulting in an increased risk of develo** a variety of chronic illnesses, such as …

The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are
still poorly understood, and current therapies are limited. Poor wound healing after trauma …

Although chronic wounds are common and continue to be a major cause of morbidity and
mortality, treatments for these conditions are lacking and often ineffective. A large body of …

Wound healing and regenerative medicine are intimately linked. While any dermal wound in
an adult human, even if treated, will result in scarring [1], the 'holy grail'of wound healing is …

Dermal fibroblasts, which make up the major cell type in the dermis, have, historically, been
considered to be relatively 'passive'cells which are responsible for the synthesis and …