An overview on the synthesis of fused pyridocoumarins with biological interest

MD Douka, KE Litinas - Molecules, 2022 - mdpi.com
Pyridocoumarins are a class of synthetic and naturally occurring organic compounds with
interesting biological activities. This review focuses on the synthetic strategies for the …

[PDF][PDF] Synthesis and anticancer activities of thiazoles, 1, 3-thiazines, and thiazolidine using chitosan-grafted-poly (vinylpyridine) as basic catalyst

SM Gomha, SM Riyadh, EA Mahmmoud… - …, 2015 - triggered.stanford.clockss.org
Three different series of ethylidenehydrazonothiazoles 5a-c, 6a-c, ethylidenehydrazono-1, 3-
thiazines 9a-i and ethylidenehydrazonothiazolidine 12 have been prepared via reactions of …

Acetylcoumarin in cyclic and heterocyclic-containing coumarins: Synthesis and biological applications

NH Nasab, F Azimian, HG Kruger, SJ Kim - Tetrahedron, 2022 - Elsevier
In design and development of bioactive compounds, coumarins as ubiquitous natural
heterocyclic compounds have been widely used. In particular, the combination of the …

Three-component synthesis of some new coumarin derivatives as anticancer agents

LA Alshabanah, LA Al-Mutabagani, SM Gomha… - Frontiers in …, 2022 - frontiersin.org
A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing
acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted …

Synthesis, molecular docking study, and cytotoxic activity against MCF cells of new Thiazole–Thiophene scaffolds

SM Gomha, SM Riyadh, B Huwaimel, MEM Zayed… - Molecules, 2022 - mdpi.com
Investigating novel compounds that may be useful in designing new, less toxic, selective,
and potent breast anticancer agents is still the main challenge for medicinal chemists. Thus …

A facile access and evaluation of some novel thiazole and 1, 3, 4-thiadiazole derivatives incorporating thiazole moiety as potent anticancer agents

SM Gomha, MR Abdelaziz, NA Kheder… - Chemistry Central …, 2017 - Springer
Background Many heterocyclic compounds containing thiazole or 1, 3, 4-thiadiazole ring in
their skeletons have been reported to possess various pharmacological activities especially …

Multicomponent synthesis, DFT calculations and molecular docking studies of novel thiazolyl-pyridazinones as potential antimicrobial agents against antibiotic …

S Abu-Melha, ZA Muhammad, AS Abouzid… - Journal of Molecular …, 2021 - Elsevier
Novel series of aryl (hetaryl) thiazolylpyridazinedione derivatives were synthesized via one-
pot three-component synthesis of maleic anhydride, thiosemicarbazide and the appropriate …

Heterocyclisation of 2, 5-diacetyl-3, 4-disubstituted-thieno [2, 3-b] thiophene bis-thiosemicarbazones leading to bis-thiazoles and bis-1, 3, 4-thiadiazoles as anti-breast …

SM Gomha, MG Badrey… - Journal of Chemical …, 2016 - journals.sagepub.com
In this paper, the synthesis of bis-thiazoles and bis-1, 3, 4-thiadiazoles linked to a
thienothiophene nucleus is described. The synthesis was achieved through interaction …

[PDF][PDF] Synthesis and antitumor activity of 1, 3, 4-thiadiazole derivatives bearing coumarine ring

SM Gomha, HM Abdel-aziz - Heterocycles, 2015 - triggered.stanford.clockss.org
In the present study, preparation of a novel series of N'-(3, 5-diphenyl-1, 3, 4-thiadiazol-2
(3H)-ylidene)-2-oxo-2H-chromene-3-carbohydrazide (8a-m) was prepared by two methods …

The Chromenopyridine Scaffold: A Privileged Platform in Drug Design

F Pedroso de Lima, M Costa, A Sousa, MF Proença - Molecules, 2024 - mdpi.com
The chromenopyridine scaffold represents an important class of heterocyclic compounds
exhibiting a broad spectrum of biological properties. This review describes novel and …