O6-methylguanine-DNA methyltransferase (MGMT) plays a crucial role in the defense
against alkylating agents that generate, among other lesions, O6-alkylguanine in DNA …

There is increasing evidence that most human cancers contain multiple mutations. By the
time a tumor is clinically detectable it may have accumulated tens of thousands of mutations …

The epidemiology and molecular biology of colorectal cancer are reviewed with a view to
understanding their interrelationship. Risk factors for colorectal neoplasia include a positive …

The human genome, comprising three billion base pairs coding for 30000–40000 genes, is
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …

There is increasing evidence that in eukaryotic cells, DNA undergoes continuous damage,
repair and resynthesis. A homeostatic equilibrium exists in which extensive DNA damage is …

DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from
bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes …

Abstract id system was used to screen yeast and human expression libraries for proteins that
interact with mismatch repair proteins. PCNA was recovered from both libraries and shown …

The MutL DNA mismatch repair protein has recently been shown to be an ATPase and to
belong to an emerging ATPase superfamily that includes DNA topoisomerase II and Hsp90 …

Viral RNA-dependent RNA polymerases (RdRPs) play essential roles in viral genome
replication and transcription. We previously reported several structural states of the …

▪ Abstract DNA mismatch repair (MMR) is one of multiple replication, repair, and
recombination processes that are required to maintain genomic stability in prokaryotes and …