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PET imaging of neuroinflammation in Alzheimer's disease
R Zhou, B Ji, Y Kong, L Qin, W Ren, Y Guan… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …
molecular imaging using positron emission tomography have provided insights into the time …
[HTML][HTML] Blood-brain barrier leakage in Alzheimer's disease: From discovery to clinical relevance
Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …
decades before the onset of clinical symptoms. One early pathological hallmark is blood …
Therapeutic B-cell depletion reverses progression of Alzheimer's disease
The function of B cells in Alzheimer's disease (AD) is not fully understood. While
immunoglobulins that target amyloid beta (Aβ) may interfere with plaque formation and …
immunoglobulins that target amyloid beta (Aβ) may interfere with plaque formation and …
Cognitive reserve in model systems for mechanistic discovery: The importance of longitudinal studies
The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …
models, directed at understanding and modifying the relationship between cognition and …
Taurine and N-acetylcysteine treatments prevent memory impairment and metabolite profile alterations in the hippocampus of high-fat diet-fed female mice
AM Garcia-Serrano, JPP Vieira… - Nutritional …, 2023 - Taylor & Francis
Background: Obesity constitutes a risk factor for cognitive impairment. In rodent models, long-
term exposure to obesogenic diets leads to hippocampal taurine accumulation. Since …
term exposure to obesogenic diets leads to hippocampal taurine accumulation. Since …
Relationship Between Reactive Astrocytes, by [18F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer's …
Reactive astrocytes play an important role in the development of Alzheimer's disease (AD).
Here, we aimed to investigate the temporospatial relationships among monoamine oxidase …
Here, we aimed to investigate the temporospatial relationships among monoamine oxidase …
Fingolimod rescues memory and improves pathological hallmarks in the 3xTg-AD model of Alzheimer's disease
SG Fagan, S Bechet, KK Dev - Molecular neurobiology, 2022 - Springer
Therapeutic strategies for Alzheimer's disease (AD) have largely focused on the regulation
of amyloid pathology while those targeting tau pathology, and inflammatory mechanisms are …
of amyloid pathology while those targeting tau pathology, and inflammatory mechanisms are …
Magnetic resonance imaging in animal models of Alzheimer's disease amyloidosis
R Ni - International Journal of Molecular Sciences, 2021 - mdpi.com
Amyloid-beta (Aβ) plays an important role in the pathogenesis of Alzheimer's disease.
Aberrant Aβ accumulation induces neuroinflammation, cerebrovascular alterations, and …
Aberrant Aβ accumulation induces neuroinflammation, cerebrovascular alterations, and …
Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer's disease: a longitudinal multimodal in vivo study
Background It has been claimed that the retina can be used as a window to study brain
disorders. However, concerning Alzheimer's disease (AD), it still remains controversial …
disorders. However, concerning Alzheimer's disease (AD), it still remains controversial …
Neuroimaging of mouse models of Alzheimer's disease
Magnetic resonance imaging (MRI) and positron emission tomography (PET) have made
great strides in the diagnosis and our understanding of Alzheimer's Disease (AD). Despite …
great strides in the diagnosis and our understanding of Alzheimer's Disease (AD). Despite …