PET imaging of neuroinflammation in Alzheimer's disease

R Zhou, B Ji, Y Kong, L Qin, W Ren, Y Guan… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

[HTML][HTML] Blood-brain barrier leakage in Alzheimer's disease: From discovery to clinical relevance

G Nehra, B Bauer, AMS Hartz - Pharmacology & therapeutics, 2022 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

Therapeutic B-cell depletion reverses progression of Alzheimer's disease

K Kim, X Wang, E Ragonnaud, M Bodogai… - Nature …, 2021 - nature.com
The function of B cells in Alzheimer's disease (AD) is not fully understood. While
immunoglobulins that target amyloid beta (Aβ) may interfere with plaque formation and …

Cognitive reserve in model systems for mechanistic discovery: The importance of longitudinal studies

JA McQuail, AR Dunn, Y Stern, CA Barnes… - Frontiers in aging …, 2021 - frontiersin.org
The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …

Taurine and N-acetylcysteine treatments prevent memory impairment and metabolite profile alterations in the hippocampus of high-fat diet-fed female mice

AM Garcia-Serrano, JPP Vieira… - Nutritional …, 2023 - Taylor & Francis
Background: Obesity constitutes a risk factor for cognitive impairment. In rodent models, long-
term exposure to obesogenic diets leads to hippocampal taurine accumulation. Since …

Relationship Between Reactive Astrocytes, by [18F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer's …

Y Kong, CA Maschio, X Shi, F **e, C Zuo… - Molecular …, 2024 - Springer
Reactive astrocytes play an important role in the development of Alzheimer's disease (AD).
Here, we aimed to investigate the temporospatial relationships among monoamine oxidase …

Fingolimod rescues memory and improves pathological hallmarks in the 3xTg-AD model of Alzheimer's disease

SG Fagan, S Bechet, KK Dev - Molecular neurobiology, 2022 - Springer
Therapeutic strategies for Alzheimer's disease (AD) have largely focused on the regulation
of amyloid pathology while those targeting tau pathology, and inflammatory mechanisms are …

Magnetic resonance imaging in animal models of Alzheimer's disease amyloidosis

R Ni - International Journal of Molecular Sciences, 2021 - mdpi.com
Amyloid-beta (Aβ) plays an important role in the pathogenesis of Alzheimer's disease.
Aberrant Aβ accumulation induces neuroinflammation, cerebrovascular alterations, and …

Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer's disease: a longitudinal multimodal in vivo study

S Chiquita, EJ Campos, J Castelhano… - Alzheimer's research & …, 2019 - Springer
Background It has been claimed that the retina can be used as a window to study brain
disorders. However, concerning Alzheimer's disease (AD), it still remains controversial …

Neuroimaging of mouse models of Alzheimer's disease

A Jullienne, MV Trinh, A Obenaus - Biomedicines, 2022 - mdpi.com
Magnetic resonance imaging (MRI) and positron emission tomography (PET) have made
great strides in the diagnosis and our understanding of Alzheimer's Disease (AD). Despite …