Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent
kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as …

Several families of protein kinases orchestrate the complex events that drive the cell cycle,
and their activity is frequently deregulated in hyperproliferative cancer cells. Although …

Tumour oncogenes include transcription factors that co-opt the general transcriptional
machinery to sustain the oncogenic state, but direct pharmacological inhibition of …

The MYC oncoproteins are thought to stimulate tumor cell growth and proliferation through
amplification of gene transcription, a mechanism that has thwarted most efforts to inhibit …

Reactive oxygen species (ROS) at the right concentration promote cell proliferation in cell
culture, stem cells, and model organisms. However, the mystery of how ROS signaling is …

A period of oocyte growth is followed by a process called oocyte maturation (the resumption
of meiosis) which occurs prior to ovulation and is a prerequisite for successful fertilization …

Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that
exhibits extremely high levels of genetic complexity and yet a relatively uniform …

Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic
options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results …

Summary Cyclin-dependent kinase 7 (CDK7) is a central regulator of the cell cycle and gene
transcription. However, little is known about its impact on genomic instability and cancer …

Estrogen receptor α (ER) ligand-binding domain (LBD) mutations are found in a substantial
number of endocrine treatment-resistant metastatic ER-positive (ER+) breast cancers. We …