Control of satellite cell function in muscle regeneration and its disruption in ageing

P Sousa-Victor, L García-Prat… - … Reviews Molecular Cell …, 2022 - nature.com
Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

Perspectives on skeletal muscle stem cells

F Relaix, M Bencze, MJ Borok, A Der Vartanian… - Nature …, 2021 - nature.com
Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle
stem cells (MuSCs). In this review, we introduce recently developed technologies and the …

Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration

DW McKellar, LD Walter, LT Song, M Mantri… - Communications …, 2021 - nature.com
Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis

G Coulis, D Jaime, C Guerrero-Juarez… - Science …, 2023 - science.org
Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …

The inflammatory speech of fibroblasts

R Schuster, JS Rockel, M Kapoor… - Immunological …, 2021 - Wiley Online Library
Activation of fibroblasts is a key event during normal tissue repair after injury and the
dysregulated repair processes that result in organ fibrosis. To most researchers, fibroblasts …

Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases

T Molina, P Fabre, NA Dumont - Open biology, 2021 - royalsocietypublishing.org
Skeletal muscle possesses a remarkable regenerative capacity that relies on the activity of
muscle stem cells, also known as satellite cells. The presence of non-myogenic cells also …

Fibro–adipogenic progenitors cross-talk in skeletal muscle: the social network

B Biferali, D Proietti, C Mozzetta, L Madaro - Frontiers in physiology, 2019 - frontiersin.org
Skeletal muscle is composed of a large and heterogeneous assortment of cell populations
that interact with each other to maintain muscle homeostasis and orchestrate regeneration …

Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury

Q Sastourné-Arrey, M Mathieu, X Contreras… - Nature …, 2023 - nature.com
Fibro-adipogenic progenitors (FAPs) play a crucial role in skeletal muscle regeneration, as
they generate a favorable niche that allows satellite cells to perform efficient muscle …

Temporal dynamics and heterogeneity of cell populations during skeletal muscle regeneration

SN Oprescu, F Yue, J Qiu, LF Brito, S Kuang - IScience, 2020 - cell.com
Mammalian skeletal muscle possesses a unique ability to regenerate, which is primarily
mediated by a population of resident muscle stem cells (MuSCs) and requires a concerted …

The jam session between muscle stem cells and the extracellular matrix in the tissue microenvironment

M Loreti, A Sacco - NPJ Regenerative medicine, 2022 - nature.com
Skeletal muscle requires a highly orchestrated coordination between multiple cell types and
their microenvironment to exert its function and to maintain its homeostasis and regenerative …