Protein S-glutathionylation is emerging as a central oxidation that regulates redox signaling
and biological processes linked to diseases. In recent years, the field of protein S …

Small pentacyclic peptides, represented by nisin, have been successfully utilized as
preservatives in the food industry and have evolved into a paradigm for understanding the …

Lanthipeptides are ribosomally‐synthesized natural products from bacteria featuring stable
thioether‐crosslinks and various bioactivities. Herein, we report on a new clade of tricyclic …

In bacteria, Ser/Thr protein kinase-like sequences are found as part of large multidomain
polypeptides that biosynthesize lanthipeptides, a class of natural products distinguished by …

Lanthipeptide synthetases are fascinating biosynthetic enzymes that install intramolecular
thioether bridges into genetically encoded peptides, typically endowing the peptide with …

Modification of the N-and C-termini of peptides enhances their stability against degradation
by exopeptidases. The biosynthetic pathways of many peptidic natural products feature …

The thioether-connected bis-amino acid lanthionine (Lan) residues are class-defining
residues of lanthipeptides. Typically, the cyclization step of lanthionine formation, which …

Genome mining has emerged as a revolutionary tool for discovering new ribosomally
synthesized and post-translationally modified peptides (RiPPs) in various genomes …

Clickable glutathione is a glutathione‐derived chemical probe designed to identify and
analyze protein S‐glutathionylation, a major cysteine oxidation in redox signaling. An …

Natural products have served various functions in human civilization for thousands of years.
From food stuffs like caffeine to pharmaceuticals such as penicillin or vancomycin, they are …