Numerous compounds have shown efficacy in limiting development of pulmonary fibrosis
using animal models, yet few of these compounds have replicated these beneficial effects in …

Laboratory mice (Mus musculus) have become the major model species for inner ear
research. The major uses of mice include gene discovery, characterization, and …

Rodent models produce data which underpin biomedical research and non-clinical drug
trials, but translation from rodents into successful clinical outcomes is often lacking. There is …

Laboratory mice have become the dominant animal model for hearing research. The mouse
cochlea operates according to standard “mammalian” principles, uses the same cochlear …

Purpose: The purpose of this study was to extend our understanding of how aging affects
normal retina function and morphology in wild-type C57BL/6J mice, by analyzing …

Although age-associated changes in kidney glomerular architecture have been described in
mice and man, the mechanisms are unknown. It is unclear if these changes can be …

Cross-species differences form barriers to translational research that ultimately hinder the
success of clinical trials, yet knowledge of species differences has yet to be systematically …

Microvascular muscle transfer is the gold standard for reanimation following chronic facial
nerve paralysis, however, despite the regenerative capacity of peripheral motor axons, poor …

The evolving microstructure and mechanical properties that promote homeostasis in the
aorta are fundamental to age-specific adaptations and disease progression. We combine ex …

Juvenile neuronal ceroid lipofuscinosis (JNCL) is a fatal lysosomal storage disease caused
by autosomal-recessive mutations in CLN3 for which no treatment exists. Symptoms appear …