A review of algorithmic approaches for cell culture media optimization

T Zhou, R Reji, RS Kairon, KH Chiam - Frontiers in bioengineering …, 2023 - frontiersin.org
Cell culture media composition and culture conditions play a crucial role in product yield,
quality and cost of production. Culture media optimization is the technique of improving …

[HTML][HTML] Artificial intelligence and machine learning applications for cultured meat

ME Todhunter, S Jubair, R Verma, R Saqe… - Frontiers in Artificial …, 2024 - frontiersin.org
Cultured meat has the potential to provide a complementary meat industry with reduced
environmental, ethical, and health impacts. However, major technological challenges …

A Beefy-R culture medium: Replacing albumin with rapeseed protein isolates

AJ Stout, ML Rittenberg, M Shub, MK Saad, AB Mirliani… - Biomaterials, 2023 - Elsevier
The development of cost-effective serum-free media is essential for the economic viability of
cultured meat. A key challenge facing this goal is the high-cost of recombinant albumin …

Toward sustainable culture media: using artificial intelligence to optimize reduced-serum formulations for cultivated meat

A Nikkhah, A Rohani, M Zarei, A Kulkarni… - Science of The Total …, 2023 - Elsevier
When considering options for future foods, cell culture approaches are at the fore, however,
culture media to support the process has been identified as a significant contributor to the …

Increasing the scope as you learn: Adaptive bayesian optimization in nested subspaces

L Papenmeier, L Nardi… - Advances in Neural …, 2022 - proceedings.neurips.cc
Recent advances have extended the scope of Bayesian optimization (BO) to expensive-to-
evaluate black-box functions with dozens of dimensions, aspiring to unlock impactful …

Spent media analysis suggests cultivated meat media will require species and cell type optimization

EN O'Neill, JC Ansel, GA Kwong, ME Plastino… - npj Science of …, 2022 - nature.com
Cell culture media design is perhaps the most significant hurdle currently facing the
commercialization of cultivated meat as an alternative source of dietary protein. Since media …

[HTML][HTML] Engineered autocrine signaling eliminates muscle cell FGF2 requirements for cultured meat production

AJ Stout, X Zhang, SM Letcher, ML Rittenberg… - Cell Reports …, 2024 - cell.com
Cultivated meat (also known as cultured meat) is a promising technology that faces
substantial cost barriers, which are currently driven by the price of media components …

Learning and optimization under epistemic uncertainty with Bayesian hybrid models

EA Eugene, KD Jones, X Gao, J Wang… - Computers & Chemical …, 2023 - Elsevier
Abstract Hybrid (ie, grey-box) models are a powerful and flexible paradigm for predictive
science and engineering. Grey-box models use data-driven constructs to incorporate …

Bounce: Reliable high-dimensional Bayesian optimization for combinatorial and mixed spaces

L Papenmeier, L Nardi… - Advances in Neural …, 2023 - proceedings.neurips.cc
Impactful applications such as materials discovery, hardware design, neural architecture
search, or portfolio optimization require optimizing high-dimensional black-box functions …

[HTML][HTML] The effect of serum-free media on the metabolic yields and growth rates of C2C12 cells in the context of cultivated meat production

EN O'Neill, M Neffling, N Randall, G Kwong, J Ansel… - Future Foods, 2023 - Elsevier
Successful commercialization of cultivated meat products as alternative sources of dietary
protein for a growing global population will require development of efficient and inexpensive …