Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Several neurodegenerative disorders involve impaired neurotransmission, and
glutamatergic neurotransmission sets a prototypical example. Glutamate is a predominant …

Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

Brain ischemia results from cardiac arrest, stroke or head trauma. These conditions can
cause severe brain damage and are a leading cause of death and long-term disability …

The roles that astrocytes play in the evolution of abnormal network excitability in chronic
neurological disorders involving brain injury, such as acquired epilepsy, are receiving …

Neuroglia, the “glue” that fills the space between neurons in the central nervous system,
takes active part in nerve cell signaling. Neuroglial cells, astroglia, oligodendroglia, and …

The volume-regulated anion channel (VRAC), also known as the volume-sensitive
outwardly rectifying (VSOR) anion channel or the volume-sensitive organic osmolyte/anion …

Astrocytes are considered the third component of the synapse, responding to
neurotransmitter release from synaptic terminals and releasing gliotransmitters—including …