An overview of anticancer platinum N-heterocyclic carbene complexes
S Zhao, Z Yang, G Jiang, S Huang, M Bian, Y Lu… - Coordination Chemistry …, 2021 - Elsevier
N-Heterocyclic carbenes (NHCs) have been introduced as a new platform for the
development of anticancer metal complexes for several decades. NHCs as strong σ-donors …
development of anticancer metal complexes for several decades. NHCs as strong σ-donors …
N‐Heterocyclic Carbene Platinum Complexes: A Big Step Forward for Effective Antitumor Compounds
S Bellemin‐Laponnaz - European Journal of Inorganic …, 2020 - Wiley Online Library
The discovery of cisplatin is an important milestone in the history of successful anticancer
drugs. This is also a notable example of the translational scientific achievement that remains …
drugs. This is also a notable example of the translational scientific achievement that remains …
Polyethylenimine, an Autophagy-Inducing Platinum-Carbene-Based Drug Carrier with Potent Toxicity towards Glioblastoma Cancer Stem Cells
C McCartin, C Dussouillez, C Bernhard, E Mathieu… - Cancers, 2022 - mdpi.com
Simple Summary The resistance of tumours to treatment and their tendency to reoccur
following successful treatment are major problems for long-term cancer patient survival …
following successful treatment are major problems for long-term cancer patient survival …
An N-heterocyclic carbene iridium (III) complex as a potent anti-cancer stem cell therapeutic
C McCartin, E Mathieu, M Dontenwill… - Chemico-Biological …, 2022 - Elsevier
Cancer stem cells (CSCs) represent a difficult to treat cellular niche within tumours due to
their unique characteristics, which give them a high propensity for resistance to classical anti …
their unique characteristics, which give them a high propensity for resistance to classical anti …
N-Heterocyclic Carbene-Platinum Complexes Featuring an Anthracenyl Moiety: Anti-Cancer Activity and DNA Interaction
A platinum (II) complex stabilized by a pyridine and an N-heterocyclic carbene ligand
featuring an anthracenyl moiety was prepared. The compound was fully characterized and …
featuring an anthracenyl moiety was prepared. The compound was fully characterized and …
The (NHC)PdBr2(2-aminopyridine) complexes: synthesis, characterization, molecular docking study, and inhibitor effects on the human serum carbonic anhydrase …
This study contains the synthesis, spectral analysis, and the enzyme inhibition effects of the
Pd-based complexes bearing both 2-aminopyridine and N-heterocyclic carbene (NHC) …
Pd-based complexes bearing both 2-aminopyridine and N-heterocyclic carbene (NHC) …
Metal N-heterocyclic carbene complexes as potential metallodrugs in antitumor therapy
YF Zhang, YK Yin, H Zhang, YF Han - Coordination Chemistry Reviews, 2024 - Elsevier
Metal complexes, which exhibit alterable oxidation states, coordination numbers, and
capacity to coordinate with different ligands, have provided a versatile platform for designing …
capacity to coordinate with different ligands, have provided a versatile platform for designing …
Synthesis and investigation of antiproliferative activity of Ru-NHC complexes against C6 and HeLa cancer cells
Abstract The 2-methylpyridine, 2-diethylaminoethyl, and isopentyl linked a series of
symmetric and unsymmetric benzimidazolium salts 2a-e were prepared and used in the …
symmetric and unsymmetric benzimidazolium salts 2a-e were prepared and used in the …
Evaluation of the Cytotoxicity of Cationic Polymers on Glioblastoma Cancer Stem Cells
C McCartin, J Blumberger, C Dussouillez… - Journal of Functional …, 2022 - mdpi.com
Cationic polymers such as polyethylenimine (PEI) have found a pervasive place in
laboratories across the world as gene delivery agents. However, their applications are not …
laboratories across the world as gene delivery agents. However, their applications are not …
IrIII−Pyridoannelated N‐Heterocyclic Carbene Complexes: Potent Theranostic Agents via Mitochondria Targeting
A Bonfiglio, C McCartin, U Carrillo… - European Journal of …, 2021 - Wiley Online Library
A novel family of IrIII complexes bearing a pyridoannelated N‐heterocyclic carbene is herein
described. The target compounds 1–5 are straightforwardly prepared and fully …
described. The target compounds 1–5 are straightforwardly prepared and fully …