Bacterial biofilm and its role in the pathogenesis of disease

LK Vestby, T Grønseth, R Simm, LL Nesse - Antibiotics, 2020 - mdpi.com
Recognition of the fact that bacterial biofilm may play a role in the pathogenesis of disease
has led to an increased focus on identifying diseases that may be biofilm-related. Biofilm …

Otitis media

AGM Schilder, T Chonmaitree, AW Cripps… - Nature reviews Disease …, 2016 - nature.com
Otitis media (OM) or middle ear inflammation is a spectrum of diseases, including acute otitis
media (AOM), otitis media with effusion (OME;'glue ear') and chronic suppurative otitis media …

Global burden of hearing impairment and ear disease

K Graydon, C Waterworth, H Miller… - The Journal of …, 2019 - cambridge.org
BackgroundHearing loss can present at birth or be acquired as a result of illness, middle-ear
disease, injury, age, overuse of certain medications, and/or induced by exposure to …

Current concepts in the pathogenesis and treatment of chronic suppurative otitis media

R Mittal, CV Lisi, R Gerring, J Mittal… - Journal of medical …, 2015 - microbiologyresearch.org
Otitis media (OM) is an inflammation of the middle ear associated with infection. Despite
appropriate therapy, acute OM (AOM) can progress to chronic suppurative OM (CSOM) …

[PDF][PDF] Chronic suppurative otitis media: a comprehensive review of epidemiology, pathogenesis, microbiology, and complications

M Khairkar, P Deshmukh, H Maity, V Deotale - Cureus, 2023 - cureus.com
Otitis media is a significant contributor to healthcare visits and the prescription of drugs. Its
associated complications and consequences pose the primary factors for preventable …

An Organ System-Based Synopsis of Pseudomonas aeruginosa Virulence

CD Morin, E Déziel, J Gauthier, RC Levesque, GW Lau - Virulence, 2021 - Taylor & Francis
Driven in part by its metabolic versatility, high intrinsic antibiotic resistance, and a large
repertoire of virulence factors, Pseudomonas aeruginosa is expertly adapted to thrive in a …

Chronic suppurative otitis media

MF Bhutta, AJ Leach, CG Brennan-Jones - The Lancet, 2024 - thelancet.com
Chronic suppurative otitis media (CSOM) is a leading global cause of potentially
preventable hearing loss in children and adults, associated with socioeconomic deprivation …

Pseudomonas aeruginosa biofilms: mechanisms of immune evasion

M Alhede, T Bjarnsholt, M Givskov, M Alhede - Advances in applied …, 2014 - Elsevier
The opportunistic gram-negative bacterium Pseudomonas aeruginosa is implicated in many
chronic infections and is readily isolated from chronic wounds, medical devices, and the …

Diabetes mellitus and the incidence of hearing loss: a cohort study

MB Kim, Y Zhang, Y Chang, S Ryu… - International journal …, 2017 - academic.oup.com
Background: To evaluate the association between diabetes mellitus (DM) and the
development of incident hearing loss. Methods: Prospective cohort study was performed in …

Challenges and solutions in polymer drug delivery for bacterial biofilm treatment: a tissue-by-tissue account

K Kasza, P Gurnani, KR Hardie, M Camara… - Advanced drug delivery …, 2021 - Elsevier
To tackle the emerging antibiotic resistance crisis, novel antimicrobial approaches are
urgently needed. Bacterial communities (biofilms) are a particular concern in this context …