Elucidating how natural selection promotes local adaptation in interaction with migration,
genetic drift and mutation is a central aim of evolutionary biology. While several conceptual …

The major histocompatibility complex (MHC) has become a paradigm for how selection can
act to maintain adaptively important genetic diversity in natural populations. Here, we review …

The adaptive immune system arose 500 million years ago in ectothermic (cold-blooded)
vertebrates. Classically, the adaptive immune system has been defined by the presence of …

There is growing interest in the possibility that genetic compatibility may drive mate choice,
including gamete choice, particularly from the perspective of understanding why females …

The major histocompatibility complex (MHC) is a gene dense region found in all jawed
vertebrates examined to date. The MHC contains a high percentage of immune genes, in …

In the past few years the DNA sequence database for molecules of the MHC (major
histocompatibility complex) has expanded greatly, yielding a more complete picture of the …

Xenopus laevis is the model of choice for evolutionary, comparative, and developmental
studies of immunity, and invaluable research tools including MHC‐defined clones, inbred …

Fascinating about classical major histocompatibility complex (MHC) molecules is their
polymorphism. The present study is a review and discussion of the fish MHC situation. The …

The major histocompatibility complex (MHC) is a large genetic region with many genes,
including the highly polymorphic classical class I and II genes that play crucial roles in …

A growing number of non-MHC-encoded class I-related molecules have been shown to
perform diverse, yet essential, functions. These include T cell presentation of bacterially …