The mucosal lining of the gut has co-evolved with a diverse microbiota over millions of
years, leading to the development of specialized mechanisms to actively limit the invasion of …

Mounting evidence from metagenomic analyses suggests that a state of pathological
microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer …

Ubiquitination regulates many essential cellular processes in eukaryotes. This post-
translational modification (PTM) is typically achieved by E1, E2, and E3 enzymes that …

Escherichia coli is a remarkable and diverse organism. This normally harmless commensal
needs only to acquire a combination of mobile genetic elements to become a highly adapted …

Enteric Escherichia coli (E. coli) are both natural flora of humans and important pathogens
causing significant morbidity and mortality worldwide. Traditionally enteric E. coli have been …

The etiology of colorectal cancer (CRC) is influenced by bacterial communities that colonize
the gastrointestinal tract. These microorganisms derive essential nutrients from indigestible …

Here, we reviewed emerging evidence on the role of the microbial community in colorectal
carcinogenesis. A healthy gut microbiota promotes intestinal homeostasis and can exert anti …

The human pathogens enteropathogenic and enterohemorrhagic Escherichia coli (EPEC
and EHEC) share a unique mechanism of colonization that results from the concerted action …

A single layer of epithelial cells separates the intestinal lumen from the underlying sterile
tissue. It is exposed to a multitude of nutrients and a large number of commensal bacteria …

Recently, an unprecedented effort has been directed at understanding the interplay between
chronic inflammation and development of cancer, with the case of inflammatory bowel …