Mesenchymal stem cells-derived exosomes for drug delivery

Y Sun, G Liu, K Zhang, Q Cao, T Liu, J Li - Stem cell research & therapy, 2021 - Springer
Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid
bilayers without organelles. In recent years, an increasing number of researchers have …

Exosomes as naturally occurring vehicles for delivery of biopharmaceuticals: insights from drug delivery to clinical perspectives

A Butreddy, N Kommineni, N Dudhipala - Nanomaterials, 2021 - mdpi.com
Exosomes as nanosized vesicles are emerging as drug delivery systems for therapeutics
owing to their natural origin, their ability to mediate intercellular communication, and their …

Optimized BMSC-derived osteoinductive exosomes immobilized in hierarchical scaffold via lyophilization for bone repair through Bmpr2/Acvr2b competitive receptor …

A Liu, D Lin, H Zhao, L Chen, B Cai, K Lin, SGF Shen - Biomaterials, 2021 - Elsevier
Mesenchymal stem cell-derived exosomes (MSC-exos), with its inherent capacity to
modulate cellular behavior, are emerging as a novel cell-free therapy for bone regeneration …

[HTML][HTML] Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities

S Varderidou-Minasian, MJ Lorenowicz - Theranostics, 2020 - ncbi.nlm.nih.gov
Mesenchymal stem/stromal cells (MSCs) are important players in tissue homeostasis and
regeneration owing to their immunomodulatory potential and release of trophic factors that …

[HTML][HTML] Therapeutic potential of exosome‐based personalized delivery platform in chronic inflammatory diseases

C Wang, M Xu, Q Fan, C Li, X Zhou - Asian journal of pharmaceutical …, 2023 - Elsevier
In the inflammatory microenvironment, there are numerous exosomes secreted by immune
cells (Macrophages, neutrophils, dendritic cells), mesenchymal stem cells (MSCs) and …

Advances in analysis of biodistribution of exosomes by molecular imaging

YW Yi, JH Lee, SY Kim, CG Pack, DH Ha… - International journal of …, 2020 - mdpi.com
Exosomes are nano-sized membranous vesicles produced by nearly all types of cells. Since
exosome-like vesicles are produced in an evolutionarily conserved manner for information …

Exosomes in clinical trial and their production in compliance with good manufacturing practice

YS Chen, EY Lin, TW Chiou, HJ Harn - Tzu Chi Medical Journal, 2020 - journals.lww.com
Abstract Exosomes, 60–200-nm extracellular vesicles secreted from cells, have been used
as an active pharmaceutical ingredient or drug carrier in disease treatment. Human-and …

Mesenchymal stem cell-derived extracellular vesicles: opportunities and challenges for clinical translation

M Maumus, P Rozier, J Boulestreau… - … in Bioengineering and …, 2020 - frontiersin.org
Extracellular vesicles (EVs), including exosomes and microvesicles, derived from
mesenchymal stem/stromal cells (MSCs) exert similar effects as their parental cells, and are …

Mesenchymal stromal cell secretome for severe COVID-19 infections: premises for the therapeutic use

E Bari, I Ferrarotti, L Saracino, S Perteghella, ML Torre… - Cells, 2020 - mdpi.com
From the end of 2019, the world population has been faced the spread of the novel
coronavirus SARS-CoV-2 responsible for COVID-19 infection. In approximately 14% of the …

Preserving extracellular vesicles for biomedical applications: consideration of storage stability before and after isolation

F Yuan, YM Li, Z Wang - Drug Delivery, 2021 - Taylor & Francis
Extracellular vesicles (EVs) are nanovesicles released by various cell types. EVs are known
for cell-to-cell communications and have potent biological activities. Despite great progress …