Cancer metastasis is a biologically complex process that remains a major challenge in the
oncology clinic, accounting for nearly all of the mortality associated with malignant …

Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity
initially reported in embryonic development, has been increasingly recognized for its …

Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …

Epithelial-mesenchymal transition (EMT) and proliferation play important roles in epithelial
cancer formation and progression, but what molecules and how they trigger EMT is largely …

Background Redox signaling caused by knockdown (KD) of Glutathione Peroxidase 2
(GPx2) in the PyMT mammary tumour model promotes metastasis via phenotypic and …

Epithelial–mesenchymal transition (EMT) is an important axis of phenotypic plasticity—a
hallmark of cancer metastasis. Raf kinase-B inhibitor protein (RKIP) and BTB and CNC …

Activation of the MUC1-C protein promotes lineage plasticity, epigenetic reprogramming,
and the cancer stem cell (CSC) state. The present studies performed on enriched …

Background p63 is a transcription factor with intrinsic pioneer factor activity and pleiotropic
functions. Transforming growth factor β (TGFβ) signaling via activation and cooperative …

Cancer cell fate has been widely ascribed to mutational changes within protein-coding
genes associated with tumor suppressors and oncogenes. In contrast, the mechanisms …

TGFβ has roles in inflammation, wound healing, epithelial to mesenchymal transition (EMT),
and cancer stem cell states, and acts as a tumor suppressor gene for squamous cell …