MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

R Rupaimoole, FJ Slack - Nature reviews Drug discovery, 2017 - nature.com
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

Transcriptional and post-transcriptional gene regulation by long non-coding RNA

IM Dykes, C Emanueli - Genomics, Proteomics and …, 2017 - academic.oup.com
Advances in genomics technology over recent years have led to the surprising discovery
that the genome is far more pervasively transcribed than was previously appreciated. Much …

Analyzing miRNA–lncRNA interactions

MD Paraskevopoulou, AG Hatzigeorgiou - Long non-coding RNAs …, 2016 - Springer
Long noncoding RNAs (lncRNAs) are noncoding transcripts usually longer than 200 nts that
have recently emerged as one of the largest and significantly diverse RNA families. The …

DIANA-LncBase v2: indexing microRNA targets on non-coding transcripts

MD Paraskevopoulou, IS Vlachos… - Nucleic acids …, 2016 - academic.oup.com
Abstract microRNAs (miRNAs) are short non-coding RNAs (ncRNAs) that act as post-
transcriptional regulators of coding gene expression. Long non-coding RNAs (lncRNAs) …

Reexamining assumptions about miRNA-guided gene silencing

A Kilikevicius, G Meister, DR Corey - Nucleic acids research, 2022 - academic.oup.com
MicroRNAs (miRNAs) are short endogenously expressed RNAs that have the potential to
regulate the expression of any RNA. This potential has led to the publication of several …

Clinical utility of circulating non-coding RNAs—an update

S Anfossi, A Babayan, K Pantel, GA Calin - Nature reviews Clinical …, 2018 - nature.com
Over the past decade, the amount of research and the number of publications on
associations between circulating small and long non-coding RNAs (ncRNAs) and cancer …

The role of long noncoding RNAs in hepatocellular carcinoma

Z Huang, JK Zhou, Y Peng, W He, C Huang - Molecular cancer, 2020 - Springer
Hepatocellular carcinoma (HCC) is the most frequent subtype of primary liver cancer and
one of the leading causes of cancer-related death worldwide. However, the molecular …

A uniform system for the annotation of vertebrate microRNA genes and the evolution of the human microRNAome

B Fromm, T Billipp, LE Peck, M Johansen… - Annual review of …, 2015 - annualreviews.org
Although microRNAs (miRNAs) are among the most intensively studied molecules of the
past 20 years, determining what is and what is not a miRNA has not been straightforward …

Noncoding RNA s in disease

E Lekka, J Hall - FEBS letters, 2018 - Wiley Online Library
Noncoding RNA s are emerging as potent and multifunctional regulators in all biological
processes. In parallel, a rapidly growing number of studies has unravelled associations …

Advances in CLIP technologies for studies of protein-RNA interactions

FCY Lee, J Ule - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) regulate all aspects in the life cycle of RNA molecules. To
elucidate the elements that guide RNA specificity, regulatory mechanisms, and functions of …