Inhibitors of mitotic protein kinases are currently being developed as non-neurotoxic
alternatives of microtubule-targeting agents (taxanes, vinca alkaloids) which provide a …

Centrioles are microtubule-based core components of centrosomes and cilia. They are
duplicated exactly once during S-phase progression. Central to formation of each new …

The polo family serine threonine kinase Plk4 has been proposed as a therapeutic target in
advanced cancers based on increased expression in primary human cancers, facilitation of …

Polo-like kinases (Plks) are critical regulatory molecules during the cell cycle process. This
family has five members: Plk1, 2, 3, 4, and 5. Plk4 has been identified as a master regulator …

Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and
cytokinesis; PLK4 is a master regulator of centriole duplication. Here, we demonstrate that …

The centriole is a multifunctional structure that organizes centrosomes and cilia and is
important for cell signaling, cell cycle progression, polarity, and motility. Defects in centriole …

The centriole is a beautiful microtubule-based organelle that is critical for the proper
execution of many fundamental cellular processes, including polarity, motility, and division …

Lysine acetylation is a widespread post-translational modification regulating various
biological processes. To characterize cellular functions of the human lysine …

Purpose Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase that regulates
centriole duplication. PLK4 deregulation causes centrosome number abnormalities, mitotic …

Centrosomes are the canonical microtubule organizing centers (MTOCs) of most
mammalian cells, including spermatocytes. Centrosomes comprise a centriole pair within a …