Sepsis is the life-threatening organ dysfunction caused by a dysregulated host response to
infection and is the leading cause of death in intensive care units. Cardiac dysfunction …

Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

Importance Patients with septic shock undergo adrenergic stress, which affects cardiac,
immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse …

Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

Perioperative organ injury is among the leading causes of morbidity and mortality of surgical
patients. Among different types of perioperative organ injury, acute kidney injury occurs …

Sepsis is a highly complex and lethal syndrome with highly heterogeneous clinical
manifestations that makes it difficult to detect and treat. It is also one of the major and most …

Septic cardiomyopathy is characterized by impaired contractive function with mitochondrial
dysregulation. Songorine is a typical active C 20-diterpene alkaloid from the lateral root of …

Background Septic cardiomyopathy worsens the prognosis of critically ill patients. Clinical
data suggest that interleukin‐1β (IL‐1β), activated by the NLRP3 inflammasome …

Importance Fluid overload occurring as a consequence of overly aggressive fluid
resuscitation may adversely affect outcome in hemodynamically unstable critically ill …

Importance β-Blocker therapy may control heart rate and attenuate the deleterious effects of
β-adrenergic receptor stimulation in septic shock. However, β-Blockers are not traditionally …