Biology, vulnerabilities and clinical applications of circulating tumour cells

A Ring, BD Nguyen-Sträuli, A Wicki, N Aceto - Nature Reviews Cancer, 2023 - nature.com
In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …

Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments

SN Lone, S Nisar, T Masoodi, M Singh, A Rizwan… - Molecular cancer, 2022 - Springer
Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly
being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have …

Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics

P Song, LR Wu, YH Yan, JX Zhang, T Chu… - Nature biomedical …, 2022 - nature.com
Cell-free DNA (cfDNA) in the circulating blood plasma of patients with cancer contains
tumour-derived DNA sequences that can serve as biomarkers for guiding therapy, for the …

[HTML][HTML] Prognostic and predictive biomarkers in gliomas

P Śledzińska, MG Bebyn, J Furtak… - International journal of …, 2021 - mdpi.com
Gliomas are the most common central nervous system tumors. New technologies, including
genetic research and advanced statistical methods, revolutionize the therapeutic approach …

[HTML][HTML] Exosome-based liquid biopsies in cancer: opportunities and challenges

W Yu, J Hurley, D Roberts, SK Chakrabortty… - Annals of …, 2021 - Elsevier
Liquid biopsy in cancer has gained momentum in clinical research and is experiencing a
boom for a variety of applications. There are significant efforts to utilize liquid biopsies in …

Current and future perspectives of liquid biopsies in genomics-driven oncology

E Heitzer, IS Haque, CES Roberts… - Nature Reviews …, 2019 - nature.com
Precision oncology seeks to leverage molecular information about cancer to improve patient
outcomes. Tissue biopsy samples are widely used to characterize tumours but are limited by …

Emerging role of deep learning‐based artificial intelligence in tumor pathology

Y Jiang, M Yang, S Wang, X Li… - Cancer communications, 2020 - Wiley Online Library
The development of digital pathology and progression of state‐of‐the‐art algorithms for
computer vision have led to increasing interest in the use of artificial intelligence (AI) …

Clinical application of advanced multi-omics tumor profiling: Sha** precision oncology of the future

D Akhoundova, MA Rubin - Cancer Cell, 2022 - cell.com
Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

Genetics and biology of prostate cancer

G Wang, D Zhao, DJ Spring… - Genes & …, 2018 - genesdev.cshlp.org
Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

Recent advances in mass spectrometry based clinical proteomics: applications to cancer research

A Macklin, S Khan, T Kislinger - Clinical proteomics, 2020 - Springer
Cancer biomarkers have transformed current practices in the oncology clinic. Continued
discovery and validation are crucial for improving early diagnosis, risk stratification, and …