Store operated calcium entry in cell migration and cancer metastasis
AS Hammad, K Machaca - Cells, 2021 - mdpi.com
Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events
including cell migration. Directional cell migration requires the polarization of both signaling …
including cell migration. Directional cell migration requires the polarization of both signaling …
New insights into the stromal interaction molecule 2 function and its impact on the immunomodulation of tumor microenvironment
S Zhou, S Liu, A Jiang, Z Li, C Duan, B Li - Cell & Bioscience, 2024 - Springer
Immune cells-enhanced immunotherapy exhibits unprecedented overall survival-
prolongation even curable in some cancer patients. Although so, most of the patients show …
prolongation even curable in some cancer patients. Although so, most of the patients show …
Platelet‐derived growth factor (PDGF)‐BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase
H Chen, Y Teng, X Chen, Z Liu, F Geng… - CNS Neuroscience …, 2021 - Wiley Online Library
Aims The neurotropic growth factor PDGF‐BB was shown to have vital neurorestorative
functions in various animal models of Parkinson's disease (PD). Previous studies indicated …
functions in various animal models of Parkinson's disease (PD). Previous studies indicated …
STIM1 controls the focal adhesion dynamics and cell migration by regulating SOCE in osteosarcoma
YS Lin, YH Lin, MH Nguyen Thi, SC Hsiao… - International journal of …, 2021 - mdpi.com
The dysregulation of store-operated Ca2+ entry (SOCE) promotes cancer progression by
changing Ca2+ levels in the cytosol or endoplasmic reticulum. Stromal interaction molecule …
changing Ca2+ levels in the cytosol or endoplasmic reticulum. Stromal interaction molecule …
[HTML][HTML] STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
AS Hammad, F Yu, J Al-Hamaq, FD Horgen… - Cell Calcium, 2023 - Elsevier
Store-operated calcium entry (SOCE) contributes to several physiological and pathological
conditions including transcription, secretion, immunodeficiencies, and cancer. SOCE has …
conditions including transcription, secretion, immunodeficiencies, and cancer. SOCE has …
PDGF/MEK/ERK axis represses Ca2+ clearance via decreasing the abundance of plasma membrane Ca2+ pump PMCA4 in pulmonary arterial smooth muscle cells
L Deng, J Chen, T Wang, B Chen… - … of Physiology-Cell …, 2021 - journals.physiology.org
Pulmonary arterial hypertension (PAH) is a rare and lethal disease characterized by
vascular remodeling and vasoconstriction, which is associated with increased intracellular …
vascular remodeling and vasoconstriction, which is associated with increased intracellular …
STIM1/SOX2 proteins are co-expressed in the tumor and microenvironmental stromal cells of pancreatic ductal adenocarcinoma and ampullary carcinoma
Pancreatic ductal adenocarcinoma (PDAC) and ampullary carcinoma (AAC) are lethal
malignancies with modest benefits from surgery. SOX2 and STIM1 have been linked to …
malignancies with modest benefits from surgery. SOX2 and STIM1 have been linked to …
Future Perspective
JB Chung, JU Chong, JY Choi, K Okazaki - Diseases of the Gallbladder, 2020 - Springer
Bile examination is not widely used clinically due to complexity in sampling with relatively
poor clinical benefits. However, in the future, cytology, liquid biopsy, and discovery of novel …
poor clinical benefits. However, in the future, cytology, liquid biopsy, and discovery of novel …
Non-viral gene coating modified IOL delivering PDGFR-α shRNA interferes with the fibrogenic process to prevent posterior capsular opacification
J Wang, Y Hu, Y Han, Q Fang, Z Chen… - Regenerative …, 2023 - academic.oup.com
Posterior capsule opacification (PCO), the most common complication after cataract surgery,
is caused by the proliferation, migration and epithelial–mesenchymal transition (EMT) of …
is caused by the proliferation, migration and epithelial–mesenchymal transition (EMT) of …
[HTML][HTML] Ligustrazine suppresses platelet aggregation through inhibiting the activities of calcium sensors
S Gao, Z Lei, H Wu - Brazilian Journal of Pharmaceutical Sciences, 2022 - SciELO Brasil
Ligustrazine is widely used for the treatment of cardiovascular diseases in traditional
Chinese medication. It has been reported that Ligustrazine decreases the concentration of …
Chinese medication. It has been reported that Ligustrazine decreases the concentration of …