SARS‐CoV‐2 in digital era: Diagnostic techniques and importance of nucleic acid quantification with digital PCRs
Studies related to clinical diagnosis and research of SARS‐CoV‐2 are important in the
current pandemic era. Although molecular biology has emphasised the importance of …
current pandemic era. Although molecular biology has emphasised the importance of …
Exploring the inhibitory potential of the antiarrhythmic drug amiodarone against Clostridioides difficile toxins TcdA and TcdB
J Schumacher, A Nienhaus, S Heber, J Matylitsky… - Gut …, 2023 - Taylor & Francis
The intestinal pathogen Clostridioides difficile is the leading cause of antibiotic-associated
diarrhea and pseudomembranous colitis in humans. The symptoms of C. difficile-associated …
diarrhea and pseudomembranous colitis in humans. The symptoms of C. difficile-associated …
[HTML][HTML] Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the …
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly
transmissible coronavirus that has caused over 6 million fatalities. SARS-CoV-2 variants …
transmissible coronavirus that has caused over 6 million fatalities. SARS-CoV-2 variants …
DRaW: prediction of COVID-19 antivirals by deep learning—an objection on using matrix factorization
Background Due to the high resource consumption of introducing a new drug, drug
repurposing plays an essential role in drug discovery. To do this, researchers examine the …
repurposing plays an essential role in drug discovery. To do this, researchers examine the …
The antiarrhythmic drugs amiodarone and dronedarone inhibit intoxication of cells with pertussis toxin
J Jia, S Lietz, H Barth, K Ernst - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Pertussis toxin (PT) is a virulent factor produced by Bordetella pertussis, the causative agent
of whoo** cough. PT exerts its pathogenic effects by ADP-ribosylating heterotrimeric G …
of whoo** cough. PT exerts its pathogenic effects by ADP-ribosylating heterotrimeric G …
Exploration of the link between COVID‐19 and alcoholic hepatitis from the perspective of bioinformatics and systems biology
T Huang, B Yu, X Zhou, H Pan, A Du… - MedComm–Future …, 2023 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been suggested to
purpose threats to health of mankind. Alcoholic hepatitis (AH) is a life‐threatening acute and …
purpose threats to health of mankind. Alcoholic hepatitis (AH) is a life‐threatening acute and …
Microbead-based extracorporeal immuno-affinity virus capture: a feasibility study to address the SARS-CoV-2 pandemic
In this paper, we report on the utilization of micro-technology based tools to fight viral
infections. Inspired by various hemoperfusion and immune-affinity capture systems, a blood …
infections. Inspired by various hemoperfusion and immune-affinity capture systems, a blood …
Application of perturbation gene expression profiles in drug discovery—From mechanism of action to quantitative modelling
High dimensional characterization of drug targets, compound effects and disease
phenotypes are crucial for increased efficiency of drug discovery. High-throughput gene …
phenotypes are crucial for increased efficiency of drug discovery. High-throughput gene …
Data-driven Drug Repurposing for Immune System-related Diseases
S Mohanty - 2024 - digitalcommons.unl.edu
In this research, we explore a data-driven approach for drug repurposing to enhance the
immunomodulatory effect by integrating pattern-based search and genome-scale metabolic …
immunomodulatory effect by integrating pattern-based search and genome-scale metabolic …
DRaW: An Objection on Using Matrix Factorization for Drug-Repurposing–Prediction of Covid-19 Antivirals by Deep Learning as a Case Study
Background: Due to the high resource consumption of introducing a new drug, drug
repurposing plays an essential role in drug discovery. To do this, researchers examine the …
repurposing plays an essential role in drug discovery. To do this, researchers examine the …