Myocardial damage is the most serious pathological consequence of cardiovascular
diseases and an important reason for their high mortality. In recent years, because of the …

Diabetic cardiomyopathy (DCM) is a pathophysiological condition of cardiac structure and
function changes in diabetic patients without coronary artery disease, hypertension, and …

Background Diabetic cardiomyopathy (DCM) is one of the common cardiovascular
complications of diabetes and a leading cause of death in diabetic patients. Mitochondrial …

BACKGROUND: Heart failure triggers a shift in myocardial metabolic substrate utilization,
favoring the ketone body 3-hydroxybutyrate as energy source. We hypothesized that 14-day …

Diabetes is a major risk factor for cardiovascular diseases, including diabetic
cardiomyopathy, atherosclerosis, myocardial infarction, and heart failure. As cardiovascular …

Hyperpolarization chemistry based on reversible exchange of parahydrogen, also known as
Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to …

Molecular metabolic imaging in humans is dominated by positron emission tomography
(PET). An emerging nonionizing alternative is hyperpolarized MRI of 13C-pyruvate, which is …

Cardiovascular disease represents the leading cause of death in people with diabetes, most
notably from macrovascular diseases such as myocardial infarction or heart failure. Diabetes …

Diabetes mellitus increases the risk of develo** heart failure, and the co-existence of both
diseases worsens cardiovascular outcomes, hospitalization, and the progression of heart …

Deuterium metabolic imaging (DMI) is an emerging clinically-applicable technique for the
non-invasive investigation of tissue metabolism. The generally short T 1 values of 2 H …