RNA-binding proteins and cancer metastasis
S Wang, Z Sun, Z Lei, HT Zhang - Seminars in cancer biology, 2022 - Elsevier
RNA-binding proteins (RBPs) can regulate gene expression through post-transcriptionally
influencing all manner of RNA biology, including alternative splicing (AS), polyadenylation …
influencing all manner of RNA biology, including alternative splicing (AS), polyadenylation …
The RNA-binding protein HuR in human cancer: a friend or foe?
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …
elements present in mRNAs whose stability and translation are subject to regulation. The …
A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation
A Fletcher, D Clift, E de Vries… - Nature …, 2023 - nature.com
Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein, which functions
as an RNA regulator. Overexpression of HuR correlates with high grade tumours and poor …
as an RNA regulator. Overexpression of HuR correlates with high grade tumours and poor …
Targeting the RNA-binding protein HuR in cancer
The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene
expression at the posttranscriptional level. Its dysregulation has been implicated in various …
expression at the posttranscriptional level. Its dysregulation has been implicated in various …
Small molecules targeting the RNA-binding protein HuR inhibit tumor growth in xenografts
The RNA-binding protein Hu antigen R (HuR) is a post-transcriptional regulator critical in
several types of diseases, including cancer, making it a promising therapeutic target. We …
several types of diseases, including cancer, making it a promising therapeutic target. We …
Drug delivery approaches for HuR-targeted therapy for lung cancer
Lung cancer (LC) is often diagnosed at an advanced stage and conventional treatments for
disease management have limitations associated with them. Novel therapeutic targets are …
disease management have limitations associated with them. Novel therapeutic targets are …
Low expression of ZFP36L1 in osteosarcoma promotes lung metastasis by inhibiting the SDC4-TGF-β signaling feedback loop
M Ma, J Zhuang, H Li, R Mi, Y Song, W Yang, Y Lu… - Oncogene, 2024 - nature.com
ZFP36L1, which is a negative regulator of gene transcripts, has been proven to regulate the
progression of several carcinomas. However, its role in sarcoma remains unknown. Here, by …
progression of several carcinomas. However, its role in sarcoma remains unknown. Here, by …
Silencing of circRNA circ_0001666 represses EMT in pancreatic cancer through upregulating miR-1251 and downregulating SOX4
R Zhang, W Zhu, C Ma, K Ai - Frontiers in molecular biosciences, 2021 - frontiersin.org
Background Pancreatic cancer (PC) is an aggressive malignancy and has a poor prognosis.
Although emerging research has revealed that circular RNAs (circRNAs) are crucial …
Although emerging research has revealed that circular RNAs (circRNAs) are crucial …
LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma
W Xu, L Chen, J Liu, Z Zhang, R Wang, Q Zhang… - Cell Death & …, 2022 - nature.com
Lung adenocarcinoma (LUAD) is one of the main causes of cancer-related mortality, with a
strong tendency to metastasize early. Transforming growth factor-β (TGF-β) signaling is a …
strong tendency to metastasize early. Transforming growth factor-β (TGF-β) signaling is a …
ELAVL1 promotes prostate cancer progression by interacting with other m6A regulators
Z Cai, H Xu, G Bai, H Hu, D Wang, H Li… - Frontiers in oncology, 2022 - frontiersin.org
N6-Methyladenosine (m6A) imbalance is an important factor in the occurrence and
development of prostate cancer (PCa). Many m6A regulators have been found to be …
development of prostate cancer (PCa). Many m6A regulators have been found to be …