Microglia are the resident macrophages of the central nervous system. Microglia possess
varied morphologies and functions. Under normal physiological conditions, microglia mainly …

There has been considerable speculation regarding the function of the dentate gyrus (DG)—
a subregion of the mammalian hippocampus—in learning and memory. In this Perspective …

One leading hypothesis suggests that memories are stored in ensembles of neurons (or
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …

Adult hippocampal neurogenesis is a unique and exceptional process in the mammalian
brain that in a lifelong and activity-dependent way generates new excitatory principal …

Post-traumatic stress disorder (PTSD) is a hypermnesic condition that develops in a subset
of individuals following exposure to severe trauma. PTSD symptoms are debilitating, and …

New neurons are continuously generated in the subgranular zone of the dentate gyrus
throughout adulthood. These new neurons gradually integrate into hippocampal circuits …

There has been interest in the function of adult neurogenesis since its discovery, by Joseph
Altman, nearly 60 years ago. While controversy curtailed follow up studies, in the 1990s a …

In humans and other mammals, memories of events are encoded by neuronal ensembles
(or engrams) in the hippocampus. The mnemonic information stored in these engrams can …

Postnatal hippocampal neurogenesis has been demonstrated to affect learning and memory
in numerous ways. Several studies have now demonstrated that increased neurogenesis …

Adult-born granule neurons pass through immature critical periods where they display
enhanced somatic excitability and afferent plasticity, which is believed to endow them with …