Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …

Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …

α-Synuclein is a small neuronal protein enriched at presynaptic termini. It is hypothesized to
play a role in neurotransmitter release and synaptic vesicle cycling, while the formation of α …

Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the
brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of …

Dendrite pathology and synaptic loss result in neural circuit dysfunction, a common feature
of neurodegenerative diseases. There is a lack of strategies that target dendritic and …

Currently, there is a lack of effective treatment for Parkinson's disease (PD). In PD patients,
aberrant methylation of SNCA (α-synuclein gene) has been reported and may be a potential …

With the recognition of the importance of the gut–brain axis in Parkinson's disease (PD)
etiology, there is increased interest in develo** therapeutic strategies that target α …

Motivation N-linked glycosylation is a frequently occurring post-translational protein
modification that serves critical functions in protein folding, stability, trafficking, and …

Various forms of Parkinson's disease, including its common sporadic form, are characterized
by prominent α‐synuclein (αSyn) aggregation in affected brain regions. However, the role of …

Parkinson's disease (PD), characterized by loss of nigrostriatal dopaminergic neurons, is
one of the most predominant neurodegenerative diseases affecting the elderly population …