Conotoxins: chemistry and biology

AH **, M Muttenthaler, S Dutertre, SWA Himaya… - Chemical …, 2019 - ACS Publications
The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …

Cysteines and disulfide bonds as structure-forming units: insights from different domains of life and the potential for characterization by NMR

C Wiedemann, A Kumar, A Lang… - Frontiers in …, 2020 - frontiersin.org
Disulfide bridges establish a fundamental element in the molecular architecture of proteins
and peptides which are involved eg, in basic biological processes or acting as toxins. NMR …

Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene

SS Pineda, YKY Chin, EAB Undheim, S Senff… - Proceedings of the …, 2020 - pnas.org
Spiders are one of the most successful venomous animals, with more than 48,000 described
species. Most spider venoms are dominated by cysteine-rich peptides with a diverse range …

Strategies for heterologous expression, synthesis, and purification of animal venom toxins

E Rivera-de-Torre, C Rimbault, TP Jenkins… - … in bioengineering and …, 2022 - frontiersin.org
Animal venoms are complex mixtures containing peptides and proteins known as toxins,
which are responsible for the deleterious effect of envenomations. Across the animal …

Modern venomics—Current insights, novel methods, and future perspectives in biological and applied animal venom research

BM von Reumont, G Anderluh, A Antunes… - …, 2022 - academic.oup.com
Venoms have evolved> 100 times in all major animal groups, and their components, known
as toxins, have been fine-tuned over millions of years into highly effective biochemical …

Venom biotechnology: casting light on nature's deadliest weapons using synthetic biology

T Lüddecke, A Paas, RJ Harris, L Talmann… - … in bioengineering and …, 2023 - frontiersin.org
Venoms are complex chemical arsenals that have evolved independently many times in the
animal kingdom. Venoms have attracted the interest of researchers because they are an …

A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2. 3

CM Hackney, P Flórez Salcedo, E Mueller, TL Koch… - Plos …, 2023 - journals.plos.org
Animal venom peptides represent valuable compounds for biomedical exploration. The
venoms of marine cone snails constitute a particularly rich source of peptide toxins, known …

[HTML][HTML] A single-chain variable fragment selected against a conformational epitope of a recombinantly produced snake toxin using phage display

C Rimbault, PD Knudsen, A Damsbo, K Boddum… - New …, 2023 - Elsevier
Phage display technology is a powerful tool for selecting monoclonal antibodies against a
diverse set of antigens. Within toxinology, however, it remains challenging to generate …

[HTML][HTML] Curses or cures: A review of the numerous benefits versus the biosecurity concerns of conotoxin research

WE Bjørn-Yoshimoto, IBL Ramiro, M Yandell… - Biomedicines, 2020 - mdpi.com
Conotoxins form a diverse group of peptide toxins found in the venom of predatory marine
cone snails. Decades of conotoxin research have provided numerous measurable scientific …

Structural analysis of a U-superfamily conotoxin containing a mini-granulin fold: Insights into key features that distinguish between the ICK and granulin folds

T Raffaelli, DT Wilson, S Dutertre, J Giribaldi… - Journal of Biological …, 2024 - jbc.org
We are entering an exciting time in structural biology where artificial intelligence can be
used to predict protein structures with greater accuracy than ever before. Extending this level …