Best practices for single-cell analysis across modalities
Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
Connecting past and present: single-cell lineage tracing
C Chen, Y Liao, G Peng - Protein & Cell, 2022 - academic.oup.com
Central to the core principle of cell theory, depicting cells' history, state and fate is a
fundamental goal in modern biology. By leveraging clonal analysis and single-cell RNA-seq …
fundamental goal in modern biology. By leveraging clonal analysis and single-cell RNA-seq …
A time-resolved, multi-symbol molecular recorder via sequential genome editing
DNA is naturally well suited to serve as a digital medium for in vivo molecular recording.
However, contemporary DNA-based memory devices are constrained in terms of the …
However, contemporary DNA-based memory devices are constrained in terms of the …
PhyloVelo enhances transcriptomic velocity field map** using monotonically expressed genes
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for studying cellular
differentiation, but accurately tracking cell fate transitions can be challenging, especially in …
differentiation, but accurately tracking cell fate transitions can be challenging, especially in …
Comprehensive spatiotemporal map** of single-cell lineages in develo** mouse brain by CRISPR-based barcoding
L **: A general framework for analyzing progenitor state dynamics via retrospective lineage barcoding
Natural and induced somatic mutations that accumulate in the genome during development
record the phylogenetic relationships of cells; whether these lineage barcodes capture the …
record the phylogenetic relationships of cells; whether these lineage barcodes capture the …
Map** lineage-traced cells across time points with moslin
Simultaneous profiling of single-cell gene expression and lineage history holds enormous
potential for studying cellular decision-making. Recent computational approaches combine …
potential for studying cellular decision-making. Recent computational approaches combine …
The lives of cells, recorded
A paradigm for biology is emerging in which cells can be genetically programmed to write
their histories into their own genomes. These records can subsequently be read, and the …
their histories into their own genomes. These records can subsequently be read, and the …
New tools for lineage tracing in cancer in vivo
During tumor evolution, cancer cells can acquire the ability to proliferate, invade neighboring
tissues, evade the immune system, and spread systemically. Tracking this process remains …
tissues, evade the immune system, and spread systemically. Tracking this process remains …
LinRace: cell division history reconstruction of single cells using paired lineage barcode and gene expression data
Lineage tracing technology using CRISPR/Cas9 genome editing has enabled simultaneous
readouts of gene expressions and lineage barcodes in single cells, which allows for …
readouts of gene expressions and lineage barcodes in single cells, which allows for …