Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …

Introduction Allosteric drugs are advantageous. However, they still face hurdles, including
identification of allosteric sites that will effectively alter the active site. Current strategies …

Despite the success of AlphaFold methods in predicting single protein structures, these
methods showed intrinsic limitations in the characterization of multiple functional …

Fold‐switching enables metamorphic proteins to reversibly interconvert between two highly
dissimilar native states to regulate their protein functions. While about 100 proteins have …

Protein folding and evolution are intimately linked phenomena. Here, we revisit the concept
of exons as potential protein folding modules across a set of 38 abundant and conserved …

The groundbreaking achievements of AlphaFold2 (AF2) approaches in protein structure
modeling marked a transformative era in structural biology. Despite the success of AF2 tools …

According to the Principle of Minimal Frustration, folded proteins can only have a minimal
number of strong energetic conflicts in their native states. However, not all interactions are …

The elegant design of protein sequence/structure/function relationships arises from the
interaction patterns between amino acid positions. A central question is how evolutionary …

The accurate prediction of protein structures with artificial intelligence has been a
spectacular success. Yet, how proteins fold into their native structures inside the cell remains …

PROteolysis TArgeting Chimeras (PROTACs), also known as Ligand-Directed Degraders
(LDDs), are an innovative class of small molecules that leverage the ubiquitin-proteasome …