Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

The discovery of clonal hematopoiesis (CH) in older individuals has changed the way
hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem …

Mutations in cancer-associated genes drive tumour outgrowth, but our knowledge of the
timing of driver mutations and subsequent clonal dynamics is limited,–. Here, using whole …

PURPOSE Clonal hematopoiesis (CH) can be transmitted from a donor to a recipient during
allogeneic hematopoietic cell transplantation. Exclusion of candidate donors with CH is …

Somatic mutations in cancer genes have been detected in clonal expansions across healthy
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …

BACKGROUND: Clonal hematopoiesis (CH), which results from an array of nonmalignant
driver gene mutations, can lead to altered immune cell function and chronic disease, and …

With aging, hematopoietic stem cells (HSCs) have an impaired ability to regenerate,
differentiate, and produce an entire repertoire of mature blood and immune cells. Owing to …

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a key treatment
option for hematologic malignancies (HMs), although it carries significant risks. Up to 30% of …

Acquired genetic mutations in hematopoietic stem or progenitor cells can lead to clonal
expansion and imbalanced blood cell production. Clonal hematopoiesis is exceptionally …

Clonal hematopoiesis (CH) defines a population of hematopoietic cells with one or more
somatic mutations/copy number alterations that can expand with time and under positive …