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TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
Vitamin C and immune cell function in inflammation and cancer
Vitamin C (ascorbate) is maintained at high levels in most immune cells and can affect many
aspects of the immune response. Intracellular levels generally respond to variations in …
aspects of the immune response. Intracellular levels generally respond to variations in …
NR4A transcription factors limit CAR T cell function in solid tumours
T cells expressing chimeric antigen receptors (CAR T cells) targeting human CD19 (hCD19)
have shown clinical efficacy against B cell malignancies,. CAR T cells have been less …
have shown clinical efficacy against B cell malignancies,. CAR T cells have been less …
Mechanisms that regulate the activities of TET proteins
K Joshi, S Liu, P Breslin SJ, J Zhang - Cellular and Molecular Life Sciences, 2022 - Springer
The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
Enhancer DNA methylation: implications for gene regulation
DNA methylation involves the addition of a methyl group to the fifth carbon of the pyrimidine
cytosine ring (5-methylcytosine, 5mC). 5mC is widespread in vertebrate genomes where it is …
cytosine ring (5-methylcytosine, 5mC). 5mC is widespread in vertebrate genomes where it is …
TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures
Enzymes of the TET family are methylcytosine dioxygenases that undergo frequent
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …
Loss of TET2 and TET3 in regulatory T cells unleashes effector function
TET enzymes oxidize 5-methylcytosine to 5-hydroxymethylcytosine and other oxidized
methylcytosines in DNA. Here we examine the role of TET proteins in regulatory T (Treg) …
methylcytosines in DNA. Here we examine the role of TET proteins in regulatory T (Treg) …
TET enzymes and 5hmC in adaptive and innate immune systems
DNA methylation is an abundant and stable epigenetic modification that allows inheritance
of information from parental to daughter cells. At active genomic regions, DNA methylation …
of information from parental to daughter cells. At active genomic regions, DNA methylation …
TET Enzymes in the Immune system: from DNA demethylation to immunotherapy, inflammation, and cancer
IF López-Moyado, M Ko, PG Hogan… - Annual Review of …, 2024 - annualreviews.org
Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …