Biological membranes are key elements for the maintenance of cell architecture and
physiology. Beyond a pure barrier separating the inner space of the cell from the outer, the …

Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

Cell migration has two opposite faces: although necessary for physiological processes such
as immune responses, it can also have detrimental effects by enabling metastatic cells to …

Cellular behavior is continuously affected by microenvironmental forces through the process
of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical …

Abstract Taxanes (Taxol/paclitaxel, Docetaxel/taxotere) are a key group of successful drugs
commonly used in chemotherapy to treat several major malignant tumors also as a front-line …

Biomechanical and biochemical cues within a tissue collaborate across length scales to
direct cell fate during development and are critical for the maintenance of tissue …

Mutations in the LaminA gene are a common cause of monogenic dilated cardiomyopathy.
Here we show that mice with a cardiomyocyte-specific Lmna deletion develop cardiac failure …

Tissues and organs provide the structural and biochemical landscapes upon which
microbial pathogens and commensals function to regulate health and disease. While flat two …

Muscle disease as a group is characterized by muscle weakness, muscle loss, and impaired
muscle function. Although the phenotype is the same, the underlying cellular pathologies …

Meiosis is the chromosomal foundation of reproduction, with errors in this important process
leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the …