The early 2000s brought a new age in the field of mass spectrometry (MS) with the
introduction of ambient ionization MS techniques. As defined by one of its early visionaries …

Owing to recent advances in mass spectrometry (MS), tens to hundreds of proteins, lipids,
and small molecules can be measured in single cells. The ability to characterize the …

A growing appreciation of the importance of cellular metabolism and revelations concerning
the extent of cell–cell heterogeneity demand metabolic characterization of individual cells …

Studying cell heterogeneity can provide a deeper understanding of biological activities, but
appropriate studies cannot be performed using traditional bulk analysis methods. The …

Single-cell analysis is critical to revealing cell-to-cell heterogeneity that would otherwise be
lost in ensemble analysis. Detailed lipidome characterization for single cells is still far from …

Cell manipulation is the foundation of biochemical studies, which demands user-friendly,
multifunctional and precise tools. Based on flow confinement principles, open microfluidics …

Cells are the fundamental units of biological systems and exhibit unique development
trajectories and molecular features. Our exploration of how the genomes orchestrate the …

Ischemic stroke (IS) is a multifactorial and heterogeneous disease. Despite years of studies,
effective strategies for the diagnosis, management and treatment of stroke are still lacking in …

Cellular heterogeneity is a phenomenon that is often observed but poorly understood.
Single-cell metabolomics can provide insights into the phenotypical variations between …

Even populations of clonal cells are heterogeneous, which requires high‐throughput
analysis methods with single‐cell sensitivity. Here, we propose a rapid, label‐free single …