Osteoporosis is a global public health problem, with fractures contributing to significant
morbidity and mortality. Although postmenopausal osteoporosis is most common, up to 30 …

Over the past decade, whole genome sequencing and other'omics' technologies have
defined pathogenic driver mutations to which tumor cells are addicted. Such addictions …

Breast cancer is treated with a multidisciplinary approach involving surgical oncology,
radiation oncology, and medical oncology. The NCCN Clinical Practice Guidelines in …

Background Adjuvant therapy with an aromatase inhibitor improves outcomes, as compared
with tamoxifen, in postmenopausal women with hormone-receptor–positive breast cancer …

Gene expression profiling has reshaped our understanding of breast cancer by defining and
characterizing four main intrinsic molecular subtypes: human epidermal growth factor …

Summary Background The Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial was
designed to compare the efficacy and safety of anastrozole (1 mg) with tamoxifen (20 mg) …

The present report focuses on the various aspects of oral delivery of anticancer drugs. The
significance of oral delivery in cancer therapeutics has been highlighted which principally …

As one of the most common metastatic sites of malignancies, bone has a unique
microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated …

Background Aromatase inhibitors are associated with consistent improvements in disease-
free survival but not in overall survival. We conducted a literature-based meta-analysis of …

Purpose To develop evidence-based guidelines, based on a systematic review, for
endocrine therapy for postmenopausal women with hormone receptor–positive breast …