The current achievements in treating glioblastoma (GBM) patients are not sufficient because
many challenges exist, such as tumor heterogeneity, the blood brain barrier, glioma stem …

Macrophages and endothelial cells (ECs) have essential roles in physiological and
pathological conditions by regulating inflammation, vascularization and tissue remodelling …

Cellular carriers for drug delivery are attractive alternatives to synthetic nanoparticles owing
to their innate homing/targeting abilities. Here, we review molecular interactions involved in …

The immune system contributes to maintaining the body's functional integrity through its two
main functions: recognizing and destroying foreign external agents (invading …

Nanoconstructs developed for biomedical purposes must overcome diverse biological
barriers before reaching the target where playing their therapeutic or diagnostic function. In …

Introduction Macrophages are involved in the normal defense of the body; however, the
varying phenotypes of macrophages and imbalance in their ratio lead to the impairment of …

Treatment of brain tumors is challenging since the blood–brain tumor barrier prevents
chemotherapy drugs from reaching the tumor site in sufficient concentrations …

Clinical translation of nanoparticle‐based drug delivery systems is hindered by an array of
challenges including poor circulation time and limited targeting. Novel approaches including …

Protein nanocages have been studied extensively, due to their unique architecture,
exceptional biocompatibility and highly customization capabilities. In particular, ferritin …

Nanoparticulate carriers, often referred to as nanoparticles (NPs), represent an important
pharmacological advance for drug protection and tissue-specific drug delivery. Accessing …